6W65
Human PARP16 in complex with RBN010860
Summary for 6W65
Entry DOI | 10.2210/pdb6w65/pdb |
Related | 4F0D 6HXR 6HXS |
Descriptor | Protein mono-ADP-ribosyltransferase PARP16, 5-{5-[(piperidin-4-yl)oxy]-2H-isoindol-2-yl}-4-(trifluoromethyl)pyridazin-3(2H)-one, CITRIC ACID, ... (7 entities in total) |
Functional Keywords | adp-ribose, parp16, artd15, artd transferase domain, adp-ribosylation, transferase-transferase inhibitor complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 96232.48 |
Authors | Swinger, K.K.,Wigle, T.J.,Kuntz, K.W. (deposition date: 2020-03-16, release date: 2020-10-07, Last modification date: 2024-03-06) |
Primary citation | Wigle, T.J.,Blackwell, D.J.,Schenkel, L.B.,Ren, Y.,Church, W.D.,Desai, H.J.,Swinger, K.K.,Santospago, A.G.,Majer, C.R.,Lu, A.Z.,Niepel, M.,Perl, N.R.,Vasbinder, M.M.,Keilhack, H.,Kuntz, K.W. In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement. Cell Chem Biol, 27:877-887.e14, 2020 Cited by PubMed: 32679093DOI: 10.1016/j.chembiol.2020.06.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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