6W4R

Structure of Tdp1 catalytic domain in complex with inhibitor XZ633p

Summary for 6W4R

• Entry DOI: 10.2210/pdb6w4r/pdb
• Descriptor: Tyrosyl-DNA phosphodiesterase 1, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-{[2-(2-hydroxyphenyl)imidazo[1,2-a]pyrazin-3-yl]amino}benzene-1,2-dicarboxylic acid, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, inhibitor, cancer drug target, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 105552.97

Authors

Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R.,Waugh, D.S. (deposition date: 2020-03-11, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Lountos, G.T.,Waugh, D.S.; Tdp1 catalytic domain; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.819 Å)