6VTA

Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with amikacin and acetyl-CoA

Summary for 6VTA

• Entry DOI: 10.2210/pdb6vta/pdb
• Related: 6VOU 6VR2 6VR3
• Descriptor: Aminoglycoside 2'-N-acetyltransferase, ACETYL COENZYME *A, (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, ... (4 entities in total)
• Functional Keywords: acetyltransferase, gnat superfamily, transferase
• Biological source: Providencia stuartii
• Total number of polymer chains: 2
• Total formula weight: 43572.29

Authors

Bassenden, A.V.,Berghuis, A.M. (deposition date: 2020-02-12, release date: 2021-06-02, Last modification date: 2023-10-11)

• Primary citation: Bassenden, A.V.,Dumalo, L.,Park, J.,Blanchet, J.,Maiti, K.,Arya, D.P.,Berghuis, A.M.; Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes.; Sci Rep, 11:11614-11614, 2021; PubMed: 34078922; DOI: 10.1038/s41598-021-89446-3

Experimental method

X-RAY DIFFRACTION (1.42 Å)