6VGI

Crystal Structures of FLAP bound to MK-866

Summary for 6VGI

• Entry DOI: 10.2210/pdb6vgi/pdb
• Descriptor: 5-lipoxygenase-activating protein, 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: 5-lipoxygenase activating protein, flap, mk-866, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 119275.96

Authors

Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H. (deposition date: 2020-01-08, release date: 2020-12-02, Last modification date: 2023-10-11)

• Primary citation: Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H.; Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).; Biochim Biophys Acta Gen Subj, 1865:129800-129800, 2020; PubMed: 33246032; DOI: 10.1016/j.bbagen.2020.129800

Experimental method

X-RAY DIFFRACTION (2.61 Å)