6VGI

Crystal Structures of FLAP bound to MK-866

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006691	biological_process	leukotriene metabolic process
A	0008047	molecular_function	enzyme activator activity
A	0016020	cellular_component	membrane
A	0019370	biological_process	leukotriene biosynthetic process
A	0031965	cellular_component	nuclear membrane
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0050544	molecular_function	arachidonate binding
A	0070207	biological_process	protein homotrimerization
A	0071277	biological_process	cellular response to calcium ion
A	0098869	biological_process	cellular oxidant detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006691	biological_process	leukotriene metabolic process
B	0008047	molecular_function	enzyme activator activity
B	0016020	cellular_component	membrane
B	0019370	biological_process	leukotriene biosynthetic process
B	0031965	cellular_component	nuclear membrane
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0050544	molecular_function	arachidonate binding
B	0070207	biological_process	protein homotrimerization
B	0071277	biological_process	cellular response to calcium ion
B	0098869	biological_process	cellular oxidant detoxification
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006691	biological_process	leukotriene metabolic process
C	0008047	molecular_function	enzyme activator activity
C	0016020	cellular_component	membrane
C	0019370	biological_process	leukotriene biosynthetic process
C	0031965	cellular_component	nuclear membrane
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0050544	molecular_function	arachidonate binding
C	0070207	biological_process	protein homotrimerization
C	0071277	biological_process	cellular response to calcium ion
C	0098869	biological_process	cellular oxidant detoxification
D	0004364	molecular_function	glutathione transferase activity
D	0004464	molecular_function	leukotriene-C4 synthase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006691	biological_process	leukotriene metabolic process
D	0008047	molecular_function	enzyme activator activity
D	0016020	cellular_component	membrane
D	0019370	biological_process	leukotriene biosynthetic process
D	0031965	cellular_component	nuclear membrane
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0050544	molecular_function	arachidonate binding
D	0070207	biological_process	protein homotrimerization
D	0071277	biological_process	cellular response to calcium ion
D	0098869	biological_process	cellular oxidant detoxification
E	0004364	molecular_function	glutathione transferase activity
E	0004464	molecular_function	leukotriene-C4 synthase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006691	biological_process	leukotriene metabolic process
E	0008047	molecular_function	enzyme activator activity
E	0016020	cellular_component	membrane
E	0019370	biological_process	leukotriene biosynthetic process
E	0031965	cellular_component	nuclear membrane
E	0046394	biological_process	carboxylic acid biosynthetic process
E	0050544	molecular_function	arachidonate binding
E	0070207	biological_process	protein homotrimerization
E	0071277	biological_process	cellular response to calcium ion
E	0098869	biological_process	cellular oxidant detoxification
F	0004364	molecular_function	glutathione transferase activity
F	0004464	molecular_function	leukotriene-C4 synthase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006691	biological_process	leukotriene metabolic process
F	0008047	molecular_function	enzyme activator activity
F	0016020	cellular_component	membrane
F	0019370	biological_process	leukotriene biosynthetic process
F	0031965	cellular_component	nuclear membrane
F	0046394	biological_process	carboxylic acid biosynthetic process
F	0050544	molecular_function	arachidonate binding
F	0070207	biological_process	protein homotrimerization
F	0071277	biological_process	cellular response to calcium ion
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue QY7 A 201

Chain	Residue
A	VAL20
A	GLY24
A	PHE25
A	HIS28
F	THR66
F	ILE113
F	LEU120
F	PHE123

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 202

Chain	Residue
A	GLY115
A	LYS116
A	ARG117
A	PHE114

---

site_id	AC3
Number of Residues	5
Details	binding site for residue QY7 B 201

Chain	Residue
B	LYS116
B	PHE123
C	GLY24
C	PHE25
C	HIS28

---

site_id	AC4
Number of Residues	5
Details	binding site for residue QY7 B 202

Chain	Residue
B	GLY24
B	PHE25
B	HIS28
D	ILE113
D	PHE123

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 B 203

Chain	Residue
B	PHE114
B	GLY115
B	LYS116
B	ARG117

---

site_id	AC6
Number of Residues	7
Details	binding site for residue QY7 C 201

Chain	Residue
C	ILE113
C	LYS116
C	LEU120
C	PHE123
D	GLY24
D	PHE25
D	HIS28

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 C 202

Chain	Residue
C	GLY115
C	LYS116
C	ARG117

---

site_id	AC8
Number of Residues	9
Details	binding site for residue QY7 E 201

Chain	Residue
A	THR66
A	ILE113
A	LYS116
A	LEU120
A	PHE123
E	GLY24
E	PHE25
E	ALA27
E	HIS28

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 E 202

Chain	Residue
E	PHE114
E	GLY115
E	LYS116
E	ARG117

---

site_id	AD1
Number of Residues	6
Details	binding site for residue QY7 F 201

Chain	Residue
E	LYS116
E	LEU120
E	PHE123
F	VAL20
F	GLY24
F	PHE25

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 F 202

Chain	Residue
F	GLY115
F	LYS116
F	ARG117

---

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GtlaFERVYtANqNC

Chain	Residue	Details
A	GLY46-CYS60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"17600184","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	426
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Intramembrane: {}

Chain

Residue

Details

---