6VGI
Crystal Structures of FLAP bound to MK-866
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | 5-lipoxygenase-activating protein | polymer | 171 | 19327.2 | 6 | UniProt (P20292) Pfam (PF01124) | Homo sapiens (Human) | FLAP, MK-886-binding protein |
| 2 | G, I, J, L, N... (A, B, C, E, F) | 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid | non-polymer | 472.1 | 6 | Chemie (QY7) | |||
| 3 | H, K, M, O, Q (A, B, C, E, F) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | R, S, T, U, V... (A, B, C, D, E...) | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 2 - 161 (UniProt: P20292)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Ala 148 | Lys 148 | conflict |
| Glu 162 | - | expression tag |
| Gly 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
| His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 115963.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3312.8 | |
| All* | Total formula weight | 119276.0 |
