6VGG

Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC

6VGG の概要

• エントリーDOI: 10.2210/pdb6vgg/pdb
• 分子名称: Transcriptional regulator ERG, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... (8 entities in total)
• 機能のキーワード: ewing sarcoma, enhancer, transcription factor, oncogenesis, prostate cancer, ets-family, runt-family, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 64725.32

構造登録者

Hou, C.,Rohr, J.,Tsodikov, O.V. (登録日: 2020-01-08, 公開日: 2020-11-25, 最終更新日: 2023-10-11)

• 主引用文献: Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V.; Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.; Structure, 29:404-412.e4, 2021; PubMed: 33275876; DOI: 10.1016/j.str.2020.11.012

実験手法

X-RAY DIFFRACTION (4.31 Å)