6V7E

Human Arginase1 Complexed with Bicyclic Inhibitor Compound 12

Summary for 6V7E

• Entry DOI: 10.2210/pdb6v7e/pdb
• Descriptor: Arginase-1, MANGANESE (II) ION, 3-[(5~{S},7~{S},8~{S})-8-azanyl-8-carboxy-1-azaspiro[4.4]nonan-7-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, ... (4 entities in total)
• Functional Keywords: agonist, arg (arginase), bicyclic, immunotherapy, metalloenzyme, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 211061.37

Authors

Palte, R.L. (deposition date: 2019-12-08, release date: 2020-05-06, Last modification date: 2023-10-11)

• Primary citation: Mitcheltree, M.J.,Li, D.,Achab, A.,Beard, A.,Chakravarthy, K.,Cheng, M.,Cho, H.,Eangoor, P.,Fan, P.,Gathiaka, S.,Kim, H.Y.,Lesburg, C.A.,Lyons, T.W.,Martinot, T.A.,Miller, J.R.,McMinn, S.,O'Neil, J.,Palani, A.,Palte, R.L.,Sauri, J.,Sloman, D.L.,Zhang, H.,Cumming, J.N.,Fischer, C.; Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.; Acs Med.Chem.Lett., 11:582-588, 2020; PubMed: 32292567; DOI: 10.1021/acsmedchemlett.0c00058

Experimental method

X-RAY DIFFRACTION (1.99 Å)