6V7E

Human Arginase1 Complexed with Bicyclic Inhibitor Compound 12

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0002250	biological_process	adaptive immune response
A	0004053	molecular_function	arginase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006525	biological_process	arginine metabolic process
A	0006527	biological_process	arginine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0019547	biological_process	arginine catabolic process to ornithine
A	0030145	molecular_function	manganese ion binding
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
A	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0000050	biological_process	urea cycle
B	0002250	biological_process	adaptive immune response
B	0004053	molecular_function	arginase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006525	biological_process	arginine metabolic process
B	0006527	biological_process	arginine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0019547	biological_process	arginine catabolic process to ornithine
B	0030145	molecular_function	manganese ion binding
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
B	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0000050	biological_process	urea cycle
C	0002250	biological_process	adaptive immune response
C	0004053	molecular_function	arginase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006525	biological_process	arginine metabolic process
C	0006527	biological_process	arginine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0019547	biological_process	arginine catabolic process to ornithine
C	0030145	molecular_function	manganese ion binding
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042130	biological_process	negative regulation of T cell proliferation
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
C	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
D	0000050	biological_process	urea cycle
D	0002250	biological_process	adaptive immune response
D	0004053	molecular_function	arginase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006525	biological_process	arginine metabolic process
D	0006527	biological_process	arginine catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
D	0019547	biological_process	arginine catabolic process to ornithine
D	0030145	molecular_function	manganese ion binding
D	0035578	cellular_component	azurophil granule lumen
D	0035580	cellular_component	specific granule lumen
D	0042130	biological_process	negative regulation of T cell proliferation
D	0042832	biological_process	defense response to protozoan
D	0045087	biological_process	innate immune response
D	0046007	biological_process	negative regulation of activated T cell proliferation
D	0046872	molecular_function	metal ion binding
D	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
D	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
D	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
E	0000050	biological_process	urea cycle
E	0002250	biological_process	adaptive immune response
E	0004053	molecular_function	arginase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006525	biological_process	arginine metabolic process
E	0006527	biological_process	arginine catabolic process
E	0016787	molecular_function	hydrolase activity
E	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
E	0019547	biological_process	arginine catabolic process to ornithine
E	0030145	molecular_function	manganese ion binding
E	0035578	cellular_component	azurophil granule lumen
E	0035580	cellular_component	specific granule lumen
E	0042130	biological_process	negative regulation of T cell proliferation
E	0042832	biological_process	defense response to protozoan
E	0045087	biological_process	innate immune response
E	0046007	biological_process	negative regulation of activated T cell proliferation
E	0046872	molecular_function	metal ion binding
E	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
E	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
E	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
F	0000050	biological_process	urea cycle
F	0002250	biological_process	adaptive immune response
F	0004053	molecular_function	arginase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006525	biological_process	arginine metabolic process
F	0006527	biological_process	arginine catabolic process
F	0016787	molecular_function	hydrolase activity
F	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
F	0019547	biological_process	arginine catabolic process to ornithine
F	0030145	molecular_function	manganese ion binding
F	0035578	cellular_component	azurophil granule lumen
F	0035580	cellular_component	specific granule lumen
F	0042130	biological_process	negative regulation of T cell proliferation
F	0042832	biological_process	defense response to protozoan
F	0045087	biological_process	innate immune response
F	0046007	biological_process	negative regulation of activated T cell proliferation
F	0046872	molecular_function	metal ion binding
F	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
F	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
F	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN A 1001

Chain	Residue
A	HIS101
A	ASP124
A	ASP128
A	ASP232
A	MN1002
A	QRA1003

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MN A 1002

Chain	Residue
A	ASP234
A	MN1001
A	QRA1003
A	ASP124
A	HIS126
A	ASP232

---

site_id	AC3
Number of Residues	22
Details	binding site for residue QRA A 1003

Chain	Residue
A	HIS101
A	ASP124
A	HIS126
A	ASP128
A	ASN130
A	SER137
A	HIS141
A	ASP181
A	ASP183
A	GLU186
A	ASP232
A	ASP234
A	THR246
A	GLU277
A	MN1001
A	MN1002
A	HOH1105
A	HOH1106
A	HOH1114
A	HOH1177
A	HOH1183
A	HOH1192

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MN B 1001

Chain	Residue
B	HIS101
B	ASP124
B	ASP128
B	ASP232
B	MN1002
B	QRA1003

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MN B 1002

Chain	Residue
B	ASP124
B	HIS126
B	ASP232
B	ASP234
B	MN1001
B	QRA1003

---

site_id	AC6
Number of Residues	20
Details	binding site for residue QRA B 1003

Chain	Residue
B	HIS101
B	ASP124
B	HIS126
B	ASP128
B	ASN130
B	SER137
B	HIS141
B	ASP183
B	GLU186
B	ASP232
B	ASP234
B	THR246
B	GLU277
B	MN1001
B	MN1002
B	HOH1111
B	HOH1119
B	HOH1160
B	HOH1165
B	HOH1177

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN C 1001

Chain	Residue
C	HIS101
C	ASP124
C	ASP128
C	ASP232
C	MN1002
C	QRA1003

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MN C 1002

Chain	Residue
C	ASP124
C	HIS126
C	ASP232
C	ASP234
C	MN1001
C	QRA1003

---

site_id	AC9
Number of Residues	21
Details	binding site for residue QRA C 1003

Chain	Residue
C	HIS101
C	ASP124
C	HIS126
C	ASP128
C	ASN130
C	SER137
C	HIS141
C	ASP181
C	ASP183
C	GLU186
C	ASP232
C	ASP234
C	THR246
C	GLU277
C	MN1001
C	MN1002
C	HOH1104
C	HOH1108
C	HOH1130
C	HOH1156
C	HOH1162

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MN D 1001

Chain	Residue
D	HIS101
D	ASP124
D	ASP128
D	ASP232
D	MN1002
D	QRA1003

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MN D 1002

Chain	Residue
D	ASP124
D	HIS126
D	ASP232
D	ASP234
D	MN1001
D	QRA1003

---

site_id	AD3
Number of Residues	21
Details	binding site for residue QRA D 1003

Chain	Residue
D	HIS101
D	ASP124
D	HIS126
D	ASP128
D	ASN130
D	SER137
D	HIS141
D	ASP183
D	GLU186
D	ASP232
D	ASP234
D	THR246
D	GLU277
D	MN1001
D	MN1002
D	HOH1102
D	HOH1103
D	HOH1127
D	HOH1143
D	HOH1153
D	HOH1172

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MN E 1001

Chain	Residue
E	HIS101
E	ASP124
E	ASP128
E	ASP232
E	MN1002
E	QRA1003

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MN E 1002

Chain	Residue
E	ASP124
E	HIS126
E	ASP232
E	ASP234
E	MN1001
E	QRA1003

---

site_id	AD6
Number of Residues	20
Details	binding site for residue QRA E 1003

Chain	Residue
E	HIS101
E	ASP124
E	HIS126
E	ASP128
E	ASN130
E	SER137
E	HIS141
E	ASP181
E	ASP183
E	GLU186
E	ASP232
E	ASP234
E	THR246
E	GLU277
E	MN1001
E	MN1002
E	HOH1104
E	HOH1120
E	HOH1126
E	HOH1158

---

site_id	AD7
Number of Residues	6
Details	binding site for residue MN F 1001

Chain	Residue
F	HIS101
F	ASP124
F	ASP128
F	ASP232
F	MN1002
F	QRA1003

---

site_id	AD8
Number of Residues	6
Details	binding site for residue MN F 1002

Chain	Residue
F	ASP124
F	HIS126
F	ASP232
F	ASP234
F	MN1001
F	QRA1003

---

site_id	AD9
Number of Residues	21
Details	binding site for residue QRA F 1003

Chain	Residue
F	HIS101
F	ASP124
F	HIS126
F	ASP128
F	ASN130
F	SER137
F	HIS141
F	ASP181
F	ASP183
F	GLU186
F	ASP232
F	ASP234
F	THR246
F	GLU277
F	MN1001
F	MN1002
F	HOH1105
F	HOH1107
F	HOH1128
F	HOH1136
F	HOH1184

---

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDVDgldPsftPAtgtpvvgG

Chain	Residue	Details
A	SER230-GLY251

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269|PubMed:16141327, ECO:0000269|PubMed:17469833, ECO:0000269|PubMed:17562323, ECO:0000269|PubMed:18802628, ECO:0000269|PubMed:21728378, ECO:0007744|PDB:1WVA, ECO:0007744|PDB:1WVB, ECO:0007744|PDB:2AEB, ECO:0007744|PDB:2PHA, ECO:0007744|PDB:2PHO, ECO:0007744|PDB:2PLL, ECO:0007744|PDB:2ZAV, ECO:0007744|PDB:3DJ8, ECO:0007744|PDB:3E6K, ECO:0007744|PDB:3E6V, ECO:0007744|PDB:3F80, ECO:0007744|PDB:3GMZ, ECO:0007744|PDB:3GN0, ECO:0007744|PDB:3KV2, ECO:0007744|PDB:3LP4, ECO:0007744|PDB:3LP7, ECO:0007744|PDB:3MFV, ECO:0007744|PDB:3MFW, ECO:0007744|PDB:3MJL, ECO:0007744|PDB:3SJT, ECO:0007744|PDB:3SKK, ECO:0007744|PDB:4FCI, ECO:0007744|PDB:4GSZ, ECO:0007744|PDB:4GWC, ECO:0007744|PDB:4GWD, ECO:0007744|PDB:4HWW, ECO:0007744|PDB:4HXQ, ECO:0007744|PDB:4IE1

Chain	Residue	Details
A	HIS101
B	ASP128
B	ASP232
B	ASP234
C	HIS101
C	ASP124
C	HIS126
C	ASP128
C	ASP232
C	ASP234
D	HIS101
A	ASP124
D	ASP124
D	HIS126
D	ASP128
D	ASP232
D	ASP234
E	HIS101
E	ASP124
E	HIS126
E	ASP128
E	ASP232
A	HIS126
E	ASP234
F	HIS101
F	ASP124
F	HIS126
F	ASP128
F	ASP232
F	ASP234
A	ASP128
A	ASP232
A	ASP234
B	HIS101
B	ASP124
B	HIS126

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744|PDB:3GMZ, ECO:0007744|PDB:3GN0, ECO:0007744|PDB:3KV2, ECO:0007744|PDB:3LP7, ECO:0007744|PDB:3THJ

Chain	Residue	Details
A	SER137
E	ASP183
F	SER137
F	ASP183
A	ASP183
B	SER137
B	ASP183
C	SER137
C	ASP183
D	SER137
D	ASP183
E	SER137

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P53608

Chain	Residue	Details
A	THR246
B	THR246
C	THR246
D	THR246
E	THR246
F	THR246

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P78540

Chain	Residue	Details
A	GLU277
B	GLU277
C	GLU277
D	GLU277
E	GLU277
F	GLU277

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q61176

Chain	Residue	Details
A	LYS17
E	LYS75
F	LYS17
F	LYS75
A	LYS75
B	LYS17
B	LYS75
C	LYS17
C	LYS75
D	LYS17
D	LYS75
E	LYS17

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER62
D	SER62
D	SER163
D	SER217
E	SER62
E	SER163
E	SER217
F	SER62
F	SER163
F	SER217
A	SER163
A	SER217
B	SER62
B	SER163
B	SER217
C	SER62
C	SER163
C	SER217

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q61176

Chain	Residue	Details
A	SER72
B	SER72
C	SER72
D	SER72
E	SER72
F	SER72

---