6V6K

EGFR(T790M/V948R) in complex with LN2057

Summary for 6V6K

• Entry DOI: 10.2210/pdb6v6k/pdb
• Descriptor: Epidermal growth factor receptor, CHLORIDE ION, N-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide, ... (4 entities in total)
• Functional Keywords: egfr, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 303242.34

Authors

Heppner, D.E.,Eck, M.J. (deposition date: 2019-12-05, release date: 2020-04-22, Last modification date: 2023-10-11)

• Primary citation: Heppner, D.E.,Gunther, M.,Wittlinger, F.,Laufer, S.A.,Eck, M.J.; Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.; J.Med.Chem., 63:4293-4305, 2020; PubMed: 32243152; DOI: 10.1021/acs.jmedchem.0c00200

Experimental method

X-RAY DIFFRACTION (2.2 Å)