6V6K
EGFR(T790M/V948R) in complex with LN2057
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A, B, C, E... | Epidermal growth factor receptor | polymer | 327 | 37392.3 | 8 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | D, A, B, C, E... | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
3 | D, A, B, C, E... | N-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | non-polymer | 477.6 | 8 | Chemie (QQJ) | |||
4 | water | water | 18.0 | 711 | Chemie (HOH) |
Sequence modifications
D, A, B, C, E, F, G, H: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 299138.3 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 4104.1 | |
All* | Total formula weight | 303242.3 |