Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004713 | molecular_function | protein tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
E | 0004672 | molecular_function | protein kinase activity |
E | 0004713 | molecular_function | protein tyrosine kinase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0006468 | biological_process | protein phosphorylation |
F | 0004672 | molecular_function | protein kinase activity |
F | 0004713 | molecular_function | protein tyrosine kinase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0006468 | biological_process | protein phosphorylation |
G | 0004672 | molecular_function | protein kinase activity |
G | 0004713 | molecular_function | protein tyrosine kinase activity |
G | 0005524 | molecular_function | ATP binding |
G | 0006468 | biological_process | protein phosphorylation |
H | 0004672 | molecular_function | protein kinase activity |
H | 0004713 | molecular_function | protein tyrosine kinase activity |
H | 0005524 | molecular_function | ATP binding |
H | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue CL D 1201 |
Chain | Residue |
D | GLY721 |
D | ALA722 |
D | PHE723 |
D | LYS745 |
D | ARG841 |
site_id | AC2 |
Number of Residues | 17 |
Details | binding site for residue QQJ D 1202 |
Chain | Residue |
D | LEU788 |
D | ILE789 |
D | MET790 |
D | GLN791 |
D | MET793 |
D | PRO794 |
D | GLY796 |
D | CYS797 |
D | ASP800 |
D | ARG841 |
D | ASN842 |
D | LEU844 |
D | ASP855 |
D | LEU718 |
D | VAL726 |
D | ALA743 |
D | LYS745 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CL A 1201 |
Chain | Residue |
A | GLY721 |
A | PHE723 |
A | LYS745 |
A | ARG841 |
A | ASP855 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue CL B 1201 |
Chain | Residue |
B | GLY721 |
B | ALA722 |
B | PHE723 |
B | LYS745 |
B | ARG841 |
B | QQJ1202 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue CL C 1201 |
Chain | Residue |
C | GLY721 |
C | ALA722 |
C | PHE723 |
C | LYS745 |
C | ARG841 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue CL E 1201 |
Chain | Residue |
E | GLY721 |
E | ALA722 |
E | PHE723 |
E | LYS745 |
E | ARG841 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue CL F 1201 |
Chain | Residue |
F | GLY721 |
F | ALA722 |
F | PHE723 |
F | LYS745 |
F | ARG841 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue CL G 1201 |
Chain | Residue |
G | GLY721 |
G | ALA722 |
G | PHE723 |
G | LYS745 |
G | ARG841 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue CL H 1201 |
Chain | Residue |
H | GLY721 |
H | ALA722 |
H | PHE723 |
H | LYS745 |
H | ARG841 |
H | ASP855 |
H | QQJ1202 |
site_id | AD1 |
Number of Residues | 23 |
Details | binding site for Di-peptide QQJ A 1202 and CYS A 797 |
Chain | Residue |
A | LEU718 |
A | VAL726 |
A | ALA743 |
A | LYS745 |
A | LEU777 |
A | LEU788 |
A | ILE789 |
A | MET790 |
A | GLN791 |
A | LEU792 |
A | MET793 |
A | PRO794 |
A | GLY796 |
A | LEU798 |
A | LEU799 |
A | ASP800 |
A | TYR801 |
A | ARG841 |
A | VAL843 |
A | LEU844 |
A | THR854 |
A | ASP855 |
A | HOH1340 |
site_id | AD2 |
Number of Residues | 23 |
Details | binding site for Di-peptide QQJ B 1202 and CYS B 797 |
Chain | Residue |
B | TYR801 |
B | ARG841 |
B | VAL843 |
B | LEU844 |
B | ASP855 |
B | CL1201 |
B | HOH1307 |
B | LEU718 |
B | VAL726 |
B | ALA743 |
B | LYS745 |
B | LEU777 |
B | LEU788 |
B | ILE789 |
B | MET790 |
B | GLN791 |
B | LEU792 |
B | MET793 |
B | PRO794 |
B | GLY796 |
B | LEU798 |
B | LEU799 |
B | ASP800 |
site_id | AD3 |
Number of Residues | 22 |
Details | binding site for Di-peptide QQJ C 1202 and CYS C 797 |
Chain | Residue |
C | VAL726 |
C | ALA743 |
C | LYS745 |
C | LEU788 |
C | ILE789 |
C | MET790 |
C | GLN791 |
C | LEU792 |
C | MET793 |
C | PRO794 |
C | GLY796 |
C | LEU798 |
C | LEU799 |
C | ASP800 |
C | TYR801 |
C | ARG841 |
C | ASN842 |
C | VAL843 |
C | LEU844 |
C | ASP855 |
C | HOH1303 |
C | HOH1330 |
site_id | AD4 |
Number of Residues | 23 |
Details | binding site for Di-peptide QQJ E 1202 and CYS E 797 |
Chain | Residue |
E | LEU718 |
E | VAL726 |
E | ALA743 |
E | LYS745 |
E | LEU777 |
E | LEU788 |
E | ILE789 |
E | MET790 |
E | GLN791 |
E | LEU792 |
E | MET793 |
E | PRO794 |
E | GLY796 |
E | LEU798 |
E | LEU799 |
E | ASP800 |
E | TYR801 |
E | ARG841 |
E | VAL843 |
E | LEU844 |
E | ASP855 |
E | HOH1328 |
E | HOH1355 |
site_id | AD5 |
Number of Residues | 23 |
Details | binding site for Di-peptide QQJ F 1202 and CYS F 797 |
Chain | Residue |
F | LEU718 |
F | VAL726 |
F | ALA743 |
F | LYS745 |
F | LEU788 |
F | ILE789 |
F | MET790 |
F | GLN791 |
F | LEU792 |
F | MET793 |
F | PRO794 |
F | GLY796 |
F | LEU798 |
F | LEU799 |
F | ASP800 |
F | TYR801 |
F | ARG841 |
F | VAL843 |
F | LEU844 |
F | THR854 |
F | ASP855 |
F | HOH1316 |
F | HOH1357 |
site_id | AD6 |
Number of Residues | 22 |
Details | binding site for Di-peptide QQJ G 1202 and CYS G 797 |
Chain | Residue |
G | LEU718 |
G | VAL726 |
G | ALA743 |
G | LYS745 |
G | LEU777 |
G | LEU788 |
G | ILE789 |
G | MET790 |
G | GLN791 |
G | MET793 |
G | GLY796 |
G | LEU798 |
G | LEU799 |
G | ASP800 |
G | TYR801 |
G | ARG841 |
G | ASN842 |
G | VAL843 |
G | LEU844 |
G | THR854 |
G | ASP855 |
G | HOH1333 |
site_id | AD7 |
Number of Residues | 22 |
Details | binding site for Di-peptide QQJ H 1202 and CYS H 797 |
Chain | Residue |
H | VAL726 |
H | ALA743 |
H | LYS745 |
H | LEU777 |
H | LEU788 |
H | ILE789 |
H | MET790 |
H | GLN791 |
H | LEU792 |
H | MET793 |
H | PRO794 |
H | GLY796 |
H | LEU798 |
H | LEU799 |
H | ASP800 |
H | TYR801 |
H | ARG841 |
H | VAL843 |
H | LEU844 |
H | THR854 |
H | ASP855 |
H | CL1201 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 28 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK |
Chain | Residue | Details |
D | LEU718-LYS745 | |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV |
Chain | Residue | Details |
D | LEU833-VAL845 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
D | ASP837 | |
A | ASP837 | |
B | ASP837 | |
C | ASP837 | |
E | ASP837 | |
F | ASP837 | |
G | ASP837 | |
H | ASP837 | |
Chain | Residue | Details |
D | LEU718 | |
A | LEU718 | |
B | LEU718 | |
C | LEU718 | |
E | LEU718 | |
F | LEU718 | |
G | LEU718 | |
H | LEU718 | |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
D | LYS745 | |
A | LYS745 | |
B | LYS745 | |
C | LYS745 | |
E | LYS745 | |
F | LYS745 | |
G | LYS745 | |
H | LYS745 | |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
D | MET790 | |
A | MET790 | |
B | MET790 | |
C | MET790 | |
E | MET790 | |
F | MET790 | |
G | MET790 | |
H | MET790 | |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
D | ASP855 | |
A | ASP855 | |
B | ASP855 | |
C | ASP855 | |
E | ASP855 | |
F | ASP855 | |
G | ASP855 | |
H | ASP855 | |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | SITE: Important for interaction with PIK3C2B |
Chain | Residue | Details |
D | TYR1016 | |
A | TYR1016 | |
B | TYR1016 | |
C | TYR1016 | |
E | TYR1016 | |
F | TYR1016 | |
G | TYR1016 | |
H | TYR1016 | |
Chain | Residue | Details |
D | LYS745 | |
A | LYS745 | |
B | LYS745 | |
C | LYS745 | |
E | LYS745 | |
F | LYS745 | |
G | LYS745 | |
H | LYS745 | |
Chain | Residue | Details |
D | TYR869 | |
A | TYR869 | |
B | TYR869 | |
C | TYR869 | |
E | TYR869 | |
F | TYR869 | |
G | TYR869 | |
H | TYR869 | |
Chain | Residue | Details |
D | SER991 | |
A | SER991 | |
B | SER991 | |
C | SER991 | |
E | SER991 | |
F | SER991 | |
G | SER991 | |
H | SER991 | |
Chain | Residue | Details |
D | SER995 | |
A | SER995 | |
B | SER995 | |
C | SER995 | |
E | SER995 | |
F | SER995 | |
G | SER995 | |
H | SER995 | |
Chain | Residue | Details |
D | TYR998 | |
A | TYR998 | |
B | TYR998 | |
C | TYR998 | |
E | TYR998 | |
F | TYR998 | |
G | TYR998 | |
H | TYR998 | |
Chain | Residue | Details |
D | TYR1016 | |
A | TYR1016 | |
B | TYR1016 | |
C | TYR1016 | |
E | TYR1016 | |
F | TYR1016 | |
G | TYR1016 | |
H | TYR1016 | |
Chain | Residue | Details |
D | LYS716 | |
B | LYS737 | |
B | LYS754 | |
B | LYS867 | |
C | LYS716 | |
C | LYS737 | |
C | LYS754 | |
C | LYS867 | |
E | LYS716 | |
E | LYS737 | |
E | LYS754 | |
D | LYS737 | |
E | LYS867 | |
F | LYS716 | |
F | LYS737 | |
F | LYS754 | |
F | LYS867 | |
G | LYS716 | |
G | LYS737 | |
G | LYS754 | |
G | LYS867 | |
H | LYS716 | |
D | LYS754 | |
H | LYS737 | |
H | LYS754 | |
H | LYS867 | |
D | LYS867 | |
A | LYS716 | |
A | LYS737 | |
A | LYS754 | |
A | LYS867 | |
B | LYS716 | |
site_id | SWS_FT_FI14 |
Number of Residues | 24 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
C | LYS929 | |
C | LYS970 | |
E | LYS929 | |
E | LYS970 | |
F | LYS929 | |
F | LYS970 | |
D | LYS929 | |
G | LYS929 | |
G | LYS970 | |
H | LYS929 | |
H | LYS970 | |
D | LYS970 | |
A | LYS929 | |
A | LYS970 | |
B | LYS929 | |
B | LYS970 | |
site_id | SWS_FT_FI15 |
Number of Residues | 16 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800 |
Chain | Residue | Details |
D | LYS757 | |
E | LYS960 | |
F | LYS757 | |
F | LYS960 | |
G | LYS757 | |
G | LYS960 | |
H | LYS757 | |
H | LYS960 | |
D | LYS960 | |
A | LYS757 | |
A | LYS960 | |
B | LYS757 | |
B | LYS960 | |
C | LYS757 | |
C | LYS960 | |
E | LYS757 | |