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6V6K

EGFR(T790M/V948R) in complex with LN2057

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0004672molecular_functionprotein kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
E0004672molecular_functionprotein kinase activity
E0004713molecular_functionprotein tyrosine kinase activity
E0005524molecular_functionATP binding
E0006468biological_processprotein phosphorylation
F0004672molecular_functionprotein kinase activity
F0004713molecular_functionprotein tyrosine kinase activity
F0005524molecular_functionATP binding
F0006468biological_processprotein phosphorylation
G0004672molecular_functionprotein kinase activity
G0004713molecular_functionprotein tyrosine kinase activity
G0005524molecular_functionATP binding
G0006468biological_processprotein phosphorylation
H0004672molecular_functionprotein kinase activity
H0004713molecular_functionprotein tyrosine kinase activity
H0005524molecular_functionATP binding
H0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CL D 1201
ChainResidue
DGLY721
DALA722
DPHE723
DLYS745
DARG841

site_idAC2
Number of Residues17
Detailsbinding site for residue QQJ D 1202
ChainResidue
DLEU788
DILE789
DMET790
DGLN791
DMET793
DPRO794
DGLY796
DCYS797
DASP800
DARG841
DASN842
DLEU844
DASP855
DLEU718
DVAL726
DALA743
DLYS745

site_idAC3
Number of Residues5
Detailsbinding site for residue CL A 1201
ChainResidue
AGLY721
APHE723
ALYS745
AARG841
AASP855

site_idAC4
Number of Residues6
Detailsbinding site for residue CL B 1201
ChainResidue
BGLY721
BALA722
BPHE723
BLYS745
BARG841
BQQJ1202

site_idAC5
Number of Residues5
Detailsbinding site for residue CL C 1201
ChainResidue
CGLY721
CALA722
CPHE723
CLYS745
CARG841

site_idAC6
Number of Residues5
Detailsbinding site for residue CL E 1201
ChainResidue
EGLY721
EALA722
EPHE723
ELYS745
EARG841

site_idAC7
Number of Residues5
Detailsbinding site for residue CL F 1201
ChainResidue
FGLY721
FALA722
FPHE723
FLYS745
FARG841

site_idAC8
Number of Residues5
Detailsbinding site for residue CL G 1201
ChainResidue
GGLY721
GALA722
GPHE723
GLYS745
GARG841

site_idAC9
Number of Residues7
Detailsbinding site for residue CL H 1201
ChainResidue
HGLY721
HALA722
HPHE723
HLYS745
HARG841
HASP855
HQQJ1202

site_idAD1
Number of Residues23
Detailsbinding site for Di-peptide QQJ A 1202 and CYS A 797
ChainResidue
ALEU718
AVAL726
AALA743
ALYS745
ALEU777
ALEU788
AILE789
AMET790
AGLN791
ALEU792
AMET793
APRO794
AGLY796
ALEU798
ALEU799
AASP800
ATYR801
AARG841
AVAL843
ALEU844
ATHR854
AASP855
AHOH1340

site_idAD2
Number of Residues23
Detailsbinding site for Di-peptide QQJ B 1202 and CYS B 797
ChainResidue
BTYR801
BARG841
BVAL843
BLEU844
BASP855
BCL1201
BHOH1307
BLEU718
BVAL726
BALA743
BLYS745
BLEU777
BLEU788
BILE789
BMET790
BGLN791
BLEU792
BMET793
BPRO794
BGLY796
BLEU798
BLEU799
BASP800

site_idAD3
Number of Residues22
Detailsbinding site for Di-peptide QQJ C 1202 and CYS C 797
ChainResidue
CVAL726
CALA743
CLYS745
CLEU788
CILE789
CMET790
CGLN791
CLEU792
CMET793
CPRO794
CGLY796
CLEU798
CLEU799
CASP800
CTYR801
CARG841
CASN842
CVAL843
CLEU844
CASP855
CHOH1303
CHOH1330

site_idAD4
Number of Residues23
Detailsbinding site for Di-peptide QQJ E 1202 and CYS E 797
ChainResidue
ELEU718
EVAL726
EALA743
ELYS745
ELEU777
ELEU788
EILE789
EMET790
EGLN791
ELEU792
EMET793
EPRO794
EGLY796
ELEU798
ELEU799
EASP800
ETYR801
EARG841
EVAL843
ELEU844
EASP855
EHOH1328
EHOH1355

site_idAD5
Number of Residues23
Detailsbinding site for Di-peptide QQJ F 1202 and CYS F 797
ChainResidue
FLEU718
FVAL726
FALA743
FLYS745
FLEU788
FILE789
FMET790
FGLN791
FLEU792
FMET793
FPRO794
FGLY796
FLEU798
FLEU799
FASP800
FTYR801
FARG841
FVAL843
FLEU844
FTHR854
FASP855
FHOH1316
FHOH1357

site_idAD6
Number of Residues22
Detailsbinding site for Di-peptide QQJ G 1202 and CYS G 797
ChainResidue
GLEU718
GVAL726
GALA743
GLYS745
GLEU777
GLEU788
GILE789
GMET790
GGLN791
GMET793
GGLY796
GLEU798
GLEU799
GASP800
GTYR801
GARG841
GASN842
GVAL843
GLEU844
GTHR854
GASP855
GHOH1333

site_idAD7
Number of Residues22
Detailsbinding site for Di-peptide QQJ H 1202 and CYS H 797
ChainResidue
HVAL726
HALA743
HLYS745
HLEU777
HLEU788
HILE789
HMET790
HGLN791
HLEU792
HMET793
HPRO794
HGLY796
HLEU798
HLEU799
HASP800
HTYR801
HARG841
HVAL843
HLEU844
HTHR854
HASP855
HCL1201

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues28
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK
ChainResidueDetails
DLEU718-LYS745

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV
ChainResidueDetails
DLEU833-VAL845

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues801
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues64
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19563760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GT8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D41","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17349580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19563760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GT8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VJN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D41","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17349580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19563760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GT8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VJN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D41","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17349580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19563760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ITX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GT8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VJN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RIY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D41","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"29192674","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues3
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23774213","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19563760","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues27
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16543144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33996800","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16543144","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"33996800","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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