6V1B

Crystal structure of the bromodomain of human BRD9 bound to I-BRD9

Summary for 6V1B

• Entry DOI: 10.2210/pdb6v1b/pdb
• Descriptor: Bromodomain-containing protein 9, 1,2-ETHANEDIOL, N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide, ... (4 entities in total)
• Functional Keywords: brd9, mswi/snf, baf, non-bet, brd, rhabdomyosarcoma antigen, i-brd9, ibrd9, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29556.70

Authors

Karim, M.R.,Chan, A.,Schonbrunn, E. (deposition date: 2019-11-20, release date: 2020-03-11, Last modification date: 2023-10-11)

• Primary citation: Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E.; Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.; J.Med.Chem., 63:3227-3237, 2020; PubMed: 32091206; DOI: 10.1021/acs.jmedchem.9b01980

Experimental method

X-RAY DIFFRACTION (1.35 Å)