6V17
Crystal structure of the bromodomain of human BRD7 bound to I-BRD9
Summary for 6V17
Entry DOI | 10.2210/pdb6v17/pdb |
Descriptor | Bromodomain-containing protein 7, CHLORIDE ION, N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide, ... (4 entities in total) |
Functional Keywords | non-bet, bromodomain, pbaf, mswi/snf, bp75, celtix1, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 29819.85 |
Authors | Karim, M.R.,Chan, A.,Schonbrunn, E. (deposition date: 2019-11-19, release date: 2020-03-11, Last modification date: 2023-10-11) |
Primary citation | Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63:3227-3237, 2020 Cited by PubMed: 32091206DOI: 10.1021/acs.jmedchem.9b01980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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