6UYC
Crystal structure of TEAD2 bound to Compound 2
Summary for 6UYC
Entry DOI | 10.2210/pdb6uyc/pdb |
Descriptor | Transcriptional enhancer factor TEF-4, N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | tead, yap binding domain, transcription inhibitor, palmitoylation inhibitor, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 54221.20 |
Authors | Noland, C.L.,Holden, J.K.,Crawford, J.J.,Zbieg, J.R.,Cunningham, C.N. (deposition date: 2019-11-12, release date: 2020-06-24, Last modification date: 2023-10-11) |
Primary citation | Holden, J.K.,Crawford, J.J.,Noland, C.L.,Schmidt, S.,Zbieg, J.R.,Lacap, J.A.,Zang, R.,Miller, G.M.,Zhang, Y.,Beroza, P.,Reja, R.,Lee, W.,Tom, J.Y.K.,Fong, R.,Steffek, M.,Clausen, S.,Hagenbeek, T.J.,Hu, T.,Zhou, Z.,Shen, H.C.,Cunningham, C.N. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep, 31:107809-107809, 2020 Cited by PubMed: 32579935DOI: 10.1016/j.celrep.2020.107809 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.658 Å) |
Structure validation
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