6UYC
Crystal structure of TEAD2 bound to Compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcriptional enhancer factor TEF-4 | polymer | 236 | 26703.1 | 2 | UniProt (Q15562) Pfam (PF17725) | Homo sapiens (Human) | TEA domain family member 2,TEAD-2 |
| 2 | C, E (A, B) | N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide | non-polymer | 346.4 | 2 | Chemie (QLV) | |||
| 3 | D (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A, B: 217 - 447 (UniProt: Q15562)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Ser 216 | - | expression tag |
| Gly 448 | - | expression tag |
| Asn 449 | - | expression tag |
| Ser 450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53406.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 814.9 | |
| All* | Total formula weight | 54221.2 |
