6UOL

Y271G DNA polymerase beta substrate complex with a templating cytosine and incoming rGTP

Summary for 6UOL

• Entry DOI: 10.2210/pdb6uol/pdb
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (10 entities in total)
• Functional Keywords: dna polymerase, ribonucleotide, oxidized nucleotide, dna damage, dna binding protein, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48510.09

Authors

Smith, M.R.,Freudenthal, B.D. (deposition date: 2019-10-15, release date: 2020-01-08, Last modification date: 2023-10-11)

• Primary citation: Smith, M.R.,Alnajjar, K.S.,Hoitsma, N.M.,Sweasy, J.B.,Freudenthal, B.D.; Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.; J.Biol.Chem., 295:1613-1622, 2020; PubMed: 31892517; DOI: 10.1074/jbc.RA119.011569

Experimental method

X-RAY DIFFRACTION (1.936 Å)