6UOL
Y271G DNA polymerase beta substrate complex with a templating cytosine and incoming rGTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (T) | DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4829.1 | 1 | synthetic construct | ||
| 2 | B (P) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3') | polymer | 10 | 3045.0 | 1 | synthetic construct | ||
| 3 | C (D) | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 1 | synthetic construct | ||
| 4 | D (A) | DNA polymerase beta | polymer | 335 | 38135.6 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 5 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | F, G, H, N, O (A) | MANGANESE (II) ION | non-polymer | 54.9 | 5 | Chemie (MN) | |||
| 7 | I, J, K (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 8 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | M (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 10 | P, Q, R, S (T, P, D, A) | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Gly 271 | Tyr 271 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47545.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 964.4 | |
| All* | Total formula weight | 48510.1 |
