6UMG

Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor

Summary for 6UMG

Entry DOI	10.2210/pdb6umg/pdb
Related	6UMH 6UMI 6UMJ
Descriptor	erenumab Fab heavy chain, IgG1, erenumab Fab light chain, IgG1, Calcitonin gene-related peptide type 1 receptor, ... (5 entities in total)
Functional Keywords	class b gpcr, complex, fragment antigen binding, membrane protein-immune system complex, membrane protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	156842.82
Authors	Mohr, C. (deposition date: 2019-10-09, release date: 2020-02-12, Last modification date: 2023-10-11)
Primary citation	Garces, F.,Mohr, C.,Zhang, L.,Huang, C.S.,Chen, Q.,King, C.,Xu, C.,Wang, Z. Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Rep, 30:1714-, 2020 Cited by PubMed: 32049005 DOI: 10.1016/j.celrep.2020.01.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation