6U7O

HIV-1 wild type protease with GRL-00819A, with phenyl-boronic-acid as P2'-ligand and with a 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand

Summary for 6U7O

Entry DOI	10.2210/pdb6u7o/pdb
Related	2IEN 4I8W 4I8Z 6BZ2 6C8X 6U7P
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	aspartic acid protease, hiv-1 protease inhibitor of grl-00819a, boronic acid, viral protein
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22386.78
Authors	Wang, Y.-F.,Kneller, D.W.,Weber, I.T. (deposition date: 2019-09-03, release date: 2019-10-09, Last modification date: 2023-10-11)
Primary citation	Ghosh, A.K.,Xia, Z.,Kovela, S.,Robinson, W.L.,Johnson, M.E.,Kneller, D.W.,Wang, Y.F.,Aoki, M.,Takamatsu, Y.,Weber, I.T.,Mitsuya, H. Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies. Chemmedchem, 14:1863-1872, 2019 Cited by PubMed: 31549492 DOI: 10.1002/cmdc.201900508 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.33 Å)

Structure validation