6TMO

Structure determination of an enhanced affinity TCR, a24b17, in complex with HLA-A*02:01 presenting a MART-1 peptide, EAAGIGILTV

Summary for 6TMO

• Entry DOI: 10.2210/pdb6tmo/pdb
• Descriptor: MHC class I antigen, Beta-2-microglobulin, EAAGIGILTV, ... (10 entities in total)
• Functional Keywords: high affinity, t-cell receptor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 95917.22

Authors

Rizkallah, P.J.,Cole, D.K. (deposition date: 2019-12-05, release date: 2020-10-07, Last modification date: 2024-01-24)

• Primary citation: Crean, R.M.,MacLachlan, B.J.,Madura, F.,Whalley, T.,Rizkallah, P.J.,Holland, C.J.,McMurran, C.,Harper, S.,Godkin, A.,Sewell, A.K.,Pudney, C.R.,van der Kamp, M.W.,Cole, D.K.; Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy.; Mol Ther Oncolytics, 18:443-456, 2020; PubMed: 32913893; DOI: 10.1016/j.omto.2020.07.008

Experimental method

X-RAY DIFFRACTION (2.1 Å)