6TKA

Crystal structure of human O-GlcNAc transferase bound to substrate 7 and a peptide from HCF-1 pro-repeat 2 (11-26)

This is a non-PDB format compatible entry.

Summary for 6TKA

• Entry DOI: 10.2210/pdb6tka/pdb
• Descriptor: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, HCF-1 pro-repeat 2 (11-26), [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S},6~{R})-3-[6-(butanoylamino)hexanoylamino]-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate, ... (5 entities in total)
• Functional Keywords: transferase complex o-glcnac ogt, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 84066.30

Authors

Meek, R.W.,Davies, G.J. (deposition date: 2019-11-28, release date: 2020-03-04, Last modification date: 2024-01-24)

• Primary citation: Alteen, M.G.,Gros, C.,Meek, R.W.,Cardoso, D.A.,Busmann, J.A.,Sangouard, G.,Deen, M.C.,Tan, H.Y.,Shen, D.L.,Russell, C.C.,Davies, G.J.,Robinson, P.J.,McCluskey, A.,Vocadlo, D.J.; A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase.; Angew.Chem.Int.Ed.Engl., 59:9601-9609, 2020; PubMed: 32092778; DOI: 10.1002/anie.202000621

Experimental method

X-RAY DIFFRACTION (1.91 Å)