6THV

X-ray structure of the Danio rerio histone deacetylase 6 (HDAC6; catalytic domain 2) in complex with Tubastatin A

Summary for 6THV

Entry DOI	10.2210/pdb6thv/pdb
Descriptor	Histone deacetylase 6, ZINC ION, POTASSIUM ION, ... (10 entities in total)
Functional Keywords	histone deacetylase 6, tubastatin a, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	40984.85
Authors	Barinka, C.,Motlova, L.,Svoboda, M. (deposition date: 2019-11-21, release date: 2020-07-15, Last modification date: 2024-01-24)
Primary citation	Shen, S.,Svoboda, M.,Zhang, G.,Cavasin, M.A.,Motlova, L.,McKinsey, T.A.,Eubanks, J.H.,Barinka, C.,Kozikowski, A.P. Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor. Acs Med.Chem.Lett., 11:706-712, 2020 Cited by PubMed: 32435374 DOI: 10.1021/acsmedchemlett.9b00560 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation