6SYP

Human DHODH bound to inhibitor IPP/CNRS-A017

This is a large structure.

Summary for 6SYP

DescriptorDihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total)
Functional Keywordsdihydroorotate dehydrogenase inhibitor complex, structural genomics, structural genomics consortium, sgc, oxidoreductase
Biological sourceHomo sapiens
Total number of polymer chains1
Total molecular weight44041.1
Authors
Primary citation
Kraemer, A.,Janin, Y.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC)
Human DHODH bound to SGC chemical probe IPP/CNRS-A017-A04
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21220 1.5% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution