Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0004151 | molecular_function | dihydroorotase activity |
| AAA | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| AAA | 0005515 | molecular_function | protein binding |
| AAA | 0005654 | cellular_component | nucleoplasm |
| AAA | 0005737 | cellular_component | cytoplasm |
| AAA | 0005739 | cellular_component | mitochondrion |
| AAA | 0005743 | cellular_component | mitochondrial inner membrane |
| AAA | 0005829 | cellular_component | cytosol |
| AAA | 0005886 | cellular_component | plasma membrane |
| AAA | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| AAA | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| AAA | 0006225 | biological_process | UDP biosynthetic process |
| AAA | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
| AAA | 0016020 | cellular_component | membrane |
| AAA | 0016491 | molecular_function | oxidoreductase activity |
| AAA | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| AAA | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| AAA | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
Functional Information from PROSITE/UniProt
| site_id | PS00911 |
| Number of Residues | 20 |
| Details | DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GfveiGSVTpkpQeGNprPR |
| Chain | Residue | Details |
| AAA | GLY114-ARG133 |
| site_id | PS00912 |
| Number of Residues | 21 |
| Details | DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGvGGVsSgqdAleKIrAGA |
| Chain | Residue | Details |
| AAA | ILE330-ALA350 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000250 |
| Chain | Residue | Details |
| AAA | MET2-ALA11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| AAA | GLN12-ALA31 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 364 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000250 |
| Chain | Residue | Details |
| AAA | THR32-ARG396 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| AAA | SER215 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 |
| Chain | Residue | Details |
| AAA | ALA96 | |
| AAA | SER120 | |
| AAA | ASN181 | |
| AAA | ASN212 | |
| AAA | LYS255 | |
| AAA | THR283 | |
| AAA | GLY306 | |
| AAA | GLY335 | |
| AAA | TYR356 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| AAA | LYS100 | |
| AAA | ASN145 | |
| AAA | ASN284 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 109 |
| Chain | Residue | Details |
| AAA | ASN145 | electrostatic stabiliser |
| AAA | PHE149 | activator, electrostatic stabiliser, enhance reactivity, polar/non-polar interaction |
| AAA | SER215 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar/non-polar interaction, proton acceptor, proton donor, proton relay |
| AAA | ASN217 | electrostatic stabiliser |
| AAA | THR218 | activator, electrostatic stabiliser, enhance reactivity, hydrogen bond acceptor |
| AAA | LYS255 | electrostatic stabiliser, hydrogen bond donor |
| AAA | ASN284 | electrostatic stabiliser |
