6SUH
Crystal structure of human transthyretin in complex with 3-O-methyltolcapone, a tolcapone analogue
Summary for 6SUH
Entry DOI | 10.2210/pdb6suh/pdb |
Descriptor | Transthyretin, 3-O-methyltolcapone (3 entities in total) |
Functional Keywords | amyloidosis, tetramer, binding protein, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32384.50 |
Authors | Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. (deposition date: 2019-09-14, release date: 2020-08-05, Last modification date: 2024-01-24) |
Primary citation | Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg.Chem., 103:104144-104144, 2020 Cited by PubMed: 32791384DOI: 10.1016/j.bioorg.2020.104144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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