6SQ0

ERa_L536S (L536S/C381S/C471S,C530S) in complex with a bridged tetracyclic indole (compound 8)

Summary for 6SQ0

Entry DOI	10.2210/pdb6sq0/pdb
Descriptor	Estrogen receptor, Bridged tetracyclic indole (3 entities in total)
Functional Keywords	oestrogen receptor, oestrogen binding domain, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	58248.06
Authors	Breed, J. (deposition date: 2019-09-03, release date: 2019-10-30, Last modification date: 2020-03-11)
Primary citation	Scott, J.S.,Breed, J.,Carbajo, R.J.,Davey, P.R.,Greenwood, R.,Huynh, H.K.,Klinowska, T.,Morrow, C.J.,Moss, T.A.,Polanski, R.,Nissink, J.W.M.,Varnes, J.,Yang, B. Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry. Acs Med.Chem.Lett., 10:1492-1497, 2019 Cited by PubMed: 31620239 DOI: 10.1021/acsmedchemlett.9b00370 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation