6SQ0

ERa_L536S (L536S/C381S/C471S,C530S) in complex with a bridged tetracyclic indole (compound 8)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	252	28655.5	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	C, D (A, B)	Bridged tetracyclic indole	non-polymer		468.5	2	Chemie (LRQ)
3	E, F (A, B)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

A, B: 307 - 554 (UniProt: P03372)

PDB	External Database	Details
Gly 303	-	expression tag
Ser 304	-	expression tag
His 305	-	expression tag
Met 306	-	expression tag
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 530	Cys 530	engineered mutation
Ser 536	Leu 536	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57311.0
Non-Polymers*	Number of molecules	2
	Total formula weight	937.0
All*	Total formula weight	58248.1

*Water molecules are not included.