6SP7

Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with Taniborbactam (VNRX-5133)

Summary for 6SP7

Entry DOI	10.2210/pdb6sp7/pdb
Descriptor	Metallo-beta-lactamase VIM-2, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	metallo-carbapenemase, antibiotic resistance, metallo-beta-lactamase superfamily, zinc-hydrolase, taniborbactam, beta-lactamase inhibitor, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	50485.64
Authors	Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2019-08-31, release date: 2020-01-22, Last modification date: 2024-01-24)
Primary citation	Liu, B.,Trout, R.E.L.,Chu, G.H.,McGarry, D.,Jackson, R.W.,Hamrick, J.C.,Daigle, D.M.,Cusick, S.M.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S.,Docquier, J.D.,Weiss, W.J.,Pevear, D.C.,Xerri, L.,Burns, C.J. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J.Med.Chem., 63:2789-2801, 2020 Cited by PubMed: 31765155 DOI: 10.1021/acs.jmedchem.9b01518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation