6SP7

Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with Taniborbactam (VNRX-5133)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
E	0008800	molecular_function	beta-lactamase activity
E	0016787	molecular_function	hydrolase activity
E	0017001	biological_process	antibiotic catabolic process
E	0042597	cellular_component	periplasmic space
E	0046677	biological_process	response to antibiotic
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS116
A	HIS118
A	HIS196
A	K9B306

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	ASP120
A	CYS221
A	HIS263
A	K9B306

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 303

Chain	Residue
A	HIS285
A	ACT304
A	ACT305
A	HIS170

---

site_id	AC4
Number of Residues	8
Details	binding site for residue ACT A 304

Chain	Residue
A	ALA135
A	THR169
A	HIS170
A	HIS285
A	ASN288
A	ZN303
A	ACT305
A	HOH425

---

site_id	AC5
Number of Residues	8
Details	binding site for residue ACT A 305

Chain	Residue
A	ALA135
A	HIS170
A	HIS285
A	ASN288
A	ZN303
A	ACT304
A	HOH424
A	HOH512

---

site_id	AC6
Number of Residues	16
Details	binding site for residue K9B A 306

Chain	Residue
A	PHE61
A	TRP87
A	HIS116
A	HIS118
A	ASP120
A	GLU149
A	HIS196
A	CYS221
A	ASN233
A	ASP236
A	HIS263
A	ZN301
A	ZN302
A	HOH416
A	HOH451
A	HOH476

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN E 301

Chain	Residue
E	HIS116
E	HIS118
E	HIS196
E	K9B306

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN E 302

Chain	Residue
E	ASP120
E	CYS221
E	HIS263
E	K9B306

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN E 303

Chain	Residue
E	HIS170
E	HIS285
E	ACT304
E	ACT305

---

site_id	AD1
Number of Residues	8
Details	binding site for residue ACT E 304

Chain	Residue
E	ALA135
E	THR169
E	HIS170
E	ASP281
E	HIS285
E	ZN303
E	ACT305
E	HOH422

---

site_id	AD2
Number of Residues	6
Details	binding site for residue ACT E 305

Chain	Residue
E	ALA135
E	HIS170
E	HIS285
E	ASN288
E	ZN303
E	ACT304

---

site_id	AD3
Number of Residues	17
Details	binding site for residue K9B E 306

Chain	Residue
E	TRP87
E	HIS116
E	HIS118
E	ASP120
E	GLU149
E	HIS196
E	CYS221
E	GLY232
E	ASN233
E	ASP236
E	HIS263
E	ZN301
E	ZN302
E	HOH431
E	HOH436
E	HOH437
E	HOH441

---