6SHC

Crystal structure of human IRE1 luminal domain Q105C

Summary for 6SHC

Entry DOI	10.2210/pdb6shc/pdb
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1 (1 entity in total)
Functional Keywords	ire1, unfolded protein response, er stress, protein quality control, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41006.37
Authors	Yan, Y.,Ron, D. (deposition date: 2019-08-06, release date: 2020-01-08, Last modification date: 2024-01-24)
Primary citation	Amin-Wetzel, N.,Neidhardt, L.,Yan, Y.,Mayer, M.P.,Ron, D. Unstructured regions in IRE1 alpha specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. Elife, 8:-, 2019 Cited by PubMed: 31873072 DOI: 10.7554/eLife.50793 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.55 Å)

Structure validation