Crystal structure of human neprilysin E584D in complex with C-type natriuretic peptide.

This is a large structure.

Summary for 6SH2

DescriptorNeprilysin, C-type natriuretic peptide fragment (CNP), N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordszinc metalloprotease, neprilysin, neutral endopeptidase., peptide binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight80834.95
Moss, S.,Subramanian, V.,Acharya, K.R. (deposition date: 2019-08-05, release date: 2019-09-25)
Primary citation
Moss, S.,Subramanian, V.,Acharya, K.R.
Crystal structure of peptide-bound neprilysin reveals key binding interactions.
Febs Lett., 2019
PubMed: 31514225 (PDB entries with the same primary citation)
DOI: 10.1002/1873-3468.13602
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28800 0.9% 2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution