6SH2
Crystal structure of human neprilysin E584D in complex with C-type natriuretic peptide.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Neprilysin | polymer | 696 | 79511.5 | 1 | UniProt (P08473) Pfam (PF05649) Pfam (PF01431) | Homo sapiens (Human) | Atriopeptidase,Common acute lymphocytic leukemia antigen,CALLA,Enkephalinase,Neutral endopeptidase 24.11,Neutral endopeptidase,Skin fibroblast elastase,SFE |
| 2 | B (DDD) | C-type natriuretic peptide fragment (CNP) | polymer | 4 | 302.3 | 1 | Homo sapiens | ||
| 3 | C, D, E, F (AAA) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | G (AAA) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | H, I (AAA) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | J (AAA) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
AAA: 54 - 749 (UniProt: P08473)
| PDB | External Database | Details |
|---|---|---|
| Asp 584 | Glu 585 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79813.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1021.1 | |
| All* | Total formula weight | 80834.9 |
