6SH1

Crystal structure of substrate-free human neprilysin E584D.

This is a large structure.

Summary for 6SH1

DescriptorNeprilysin, N-ACETYL-D-GLUCOSAMINE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordszinc metalloprotease, neprilysin, neutral endopeptidase., peptide binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight161109.64
Authors
Moss, S.,Subramanian, V.,Acharya, K.R. (deposition date: 2019-08-05, release date: 2019-09-25)
Primary citation
Moss, S.,Subramanian, V.,Acharya, K.R.
Crystal structure of peptide-bound neprilysin reveals key binding interactions.
Febs Lett., 2019
PubMed: 31514225 (PDB entries with the same primary citation)
DOI: 10.1002/1873-3468.13602
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26820 0.3% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution