Crystal structure of substrate-free human neprilysin E584D.

This is a large structure.

Summary for 6SH1

DescriptorNeprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordszinc metalloprotease, neprilysin, neutral endopeptidase., peptide binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight161109.64
Moss, S.,Subramanian, V.,Acharya, K.R. (deposition date: 2019-08-05, release date: 2019-09-25, Last modification date: 2020-07-29)
Primary citation
Moss, S.,Subramanian, V.,Acharya, K.R.
Crystal structure of peptide-bound neprilysin reveals key binding interactions.
Febs Lett., 594:327-336, 2020
PubMed: 31514225 (PDB entries with the same primary citation)
DOI: 10.1002/1873-3468.13602
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26820 0.3% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21