6S5V

Crystal structure of the Cap-Midlink region of the H5N1 Influenza A virus polymerase in complex with a Cap-domain binding analogue

This is a non-PDB format compatible entry.

Summary for 6S5V

• Entry DOI: 10.2210/pdb6s5v/pdb
• Descriptor: Polymerase basic protein 2, (1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: influenza a, h5n1, influenza polymerase, cap binding analogue, viral protein
• Biological source: Influenza A virus (A/duck/Fujian/13/2002(H5N1))
• Total number of polymer chains: 2
• Total formula weight: 70068.95

Authors

Keown, J.R.,Fodor, E.,Grimes, J.M. (deposition date: 2019-07-02, release date: 2019-11-06, Last modification date: 2024-05-15)

• Primary citation: McGowan, D.C.,Balemans, W.,Embrechts, W.,Motte, M.,Keown, J.R.,Buyck, C.,Corbera, J.,Funes, M.,Moreno, L.,Cooymans, L.,Tahri, A.,Eymard, J.,Stoops, B.,Strijbos, R.,Van den Berg, J.,Fodor, E.,Grimes, J.M.,Koul, A.,Jonckers, T.H.M.,Raboisson, P.,Guillemont, J.; Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.; J.Med.Chem., 62:9680-9690, 2019; PubMed: 31647875; DOI: 10.1021/acs.jmedchem.9b01091

Experimental method

X-RAY DIFFRACTION (1.35 Å)