6S5V

Crystal structure of the Cap-Midlink region of the H5N1 Influenza A virus polymerase in complex with a Cap-domain binding analogue

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAAA, ABAA	Polymerase basic protein 2	polymer	304	34249.2	2	UniProt (Q6E3N3) Pfam (PF20950) Pfam (PF00604) In PDB	Influenza A virus (A/duck/Fujian/13/2002(H5N1))	RNA-directed RNA polymerase subunit P3
2	AAAA, ABAA	(1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid	non-polymer		418.4	3	Chemie (KWN)
3	AAAA, ABAA	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	ABAA	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
5		water	water		18.0	421	Chemie (HOH)

Sequence modifications

AAAA, ABAA: 247 - 536 (UniProt: Q6E3N3)

PDB	External Database	Details
His 233	-	expression tag
His 234	-	expression tag
His 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
Gly 239	-	expression tag
Glu 240	-	expression tag
Asn 241	-	expression tag
Leu 242	-	expression tag
Tyr 243	-	expression tag
Phe 244	-	expression tag
Gln 245	-	expression tag
Gly 246	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68498.3
Non-Polymers*	Number of molecules	7
	Total formula weight	1570.6
All*	Total formula weight	70069.0

*Water molecules are not included.