Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B2

This is a large structure.

Summary for 6RXV

EMDB information10053
DescriptorPeriodic tryptophan protein 2-like protein, Utp2, Utp3, ... (66 entities in total)
Functional Keywordsribosome, ribosome biogenesis, rrna
Biological sourceChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Total number of polymer chains68
Total molecular weight4670591.5
Cheng, J.,Kellner, N.,Griesel, S.,Berninghausen, O.,Beckmann, R.,Hurt, E. (deposition date: 2019-06-10, release date: 2019-08-14)
Primary citation
Cheng, J.,Bassler, J.,Fischer, P.,Lau, B.,Kellner, N.,Kunze, R.,Griesel, S.,Kallas, M.,Berninghausen, O.,Strauss, D.,Beckmann, R.,Hurt, E.
Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Mol.Cell, 2019
PubMed: 31378463 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2019.06.032
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone9 0.1% 2.9% 0.48MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures