Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RXV

Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Ca	0003735	molecular_function	structural constituent of ribosome
Ca	0005737	cellular_component	cytoplasm
Ca	0005840	cellular_component	ribosome
Ca	0006412	biological_process	translation
Ca	0022627	cellular_component	cytosolic small ribosomal subunit
Ca	1990904	cellular_component	ribonucleoprotein complex
CA	0003723	molecular_function	RNA binding
CA	0006364	biological_process	rRNA processing
CA	0008168	molecular_function	methyltransferase activity
CA	0032259	biological_process	methylation
Cb	0003723	molecular_function	RNA binding
Cb	0003735	molecular_function	structural constituent of ribosome
Cb	0005840	cellular_component	ribosome
Cb	0006412	biological_process	translation
Cb	0019843	molecular_function	rRNA binding
Cb	1990904	cellular_component	ribonucleoprotein complex
CB	0003723	molecular_function	RNA binding
CB	0006364	biological_process	rRNA processing
CB	0008168	molecular_function	methyltransferase activity
CB	0032259	biological_process	methylation
Cc	0003723	molecular_function	RNA binding
Cc	0003735	molecular_function	structural constituent of ribosome
Cc	0005840	cellular_component	ribosome
Cc	0006412	biological_process	translation
Cc	0015935	cellular_component	small ribosomal subunit
Cc	1990904	cellular_component	ribonucleoprotein complex
CC	0030515	molecular_function	snoRNA binding
CC	0031428	cellular_component	box C/D methylation guide snoRNP complex
CC	0032040	cellular_component	small-subunit processome
Cd	0003735	molecular_function	structural constituent of ribosome
Cd	0005840	cellular_component	ribosome
Cd	0006412	biological_process	translation
Cd	1990904	cellular_component	ribonucleoprotein complex
CD	0005634	cellular_component	nucleus
CD	0005730	cellular_component	nucleolus
CD	0030515	molecular_function	snoRNA binding
CD	0031428	cellular_component	box C/D methylation guide snoRNP complex
CD	0032040	cellular_component	small-subunit processome
CD	1990904	cellular_component	ribonucleoprotein complex
Ce	0003735	molecular_function	structural constituent of ribosome
Ce	0005840	cellular_component	ribosome
Ce	0006364	biological_process	rRNA processing
Ce	0006412	biological_process	translation
Ce	0022627	cellular_component	cytosolic small ribosomal subunit
Ce	0030686	cellular_component	90S preribosome
Ce	0032040	cellular_component	small-subunit processome
Ce	0042274	biological_process	ribosomal small subunit biogenesis
Ce	1990904	cellular_component	ribonucleoprotein complex
CE	0000398	biological_process	mRNA splicing, via spliceosome
CE	0003723	molecular_function	RNA binding
CE	0005634	cellular_component	nucleus
CE	0005681	cellular_component	spliceosomal complex
CE	0005730	cellular_component	nucleolus
CE	0006397	biological_process	mRNA processing
CE	0008380	biological_process	RNA splicing
CE	0042254	biological_process	ribosome biogenesis
CE	1990904	cellular_component	ribonucleoprotein complex
Cf	0003735	molecular_function	structural constituent of ribosome
Cf	0005840	cellular_component	ribosome
Cf	0006412	biological_process	translation
Cf	1990904	cellular_component	ribonucleoprotein complex
CF	0000398	biological_process	mRNA splicing, via spliceosome
CF	0003723	molecular_function	RNA binding
CF	0005634	cellular_component	nucleus
CF	0005681	cellular_component	spliceosomal complex
CF	0005730	cellular_component	nucleolus
CF	0006397	biological_process	mRNA processing
CF	0008380	biological_process	RNA splicing
CF	0042254	biological_process	ribosome biogenesis
CF	1990904	cellular_component	ribonucleoprotein complex
Cg	0003723	molecular_function	RNA binding
Cg	0003735	molecular_function	structural constituent of ribosome
Cg	0005840	cellular_component	ribosome
Cg	0006412	biological_process	translation
Cg	0015935	cellular_component	small ribosomal subunit
Cg	0019843	molecular_function	rRNA binding
Cg	0022627	cellular_component	cytosolic small ribosomal subunit
Cg	0042274	biological_process	ribosomal small subunit biogenesis
Cg	0043226	cellular_component	organelle
Cg	1990904	cellular_component	ribonucleoprotein complex
CG	0005634	cellular_component	nucleus
CG	0034511	molecular_function	U3 snoRNA binding
Ch	0003735	molecular_function	structural constituent of ribosome
Ch	0005730	cellular_component	nucleolus
Ch	0005840	cellular_component	ribosome
Ch	0006412	biological_process	translation
Ch	0022627	cellular_component	cytosolic small ribosomal subunit
Ch	0070181	molecular_function	small ribosomal subunit rRNA binding
Ch	1990904	cellular_component	ribonucleoprotein complex
CH	0003824	molecular_function	catalytic activity
CH	0005634	cellular_component	nucleus
CH	0005730	cellular_component	nucleolus
CH	0006396	biological_process	RNA processing
CH	0042254	biological_process	ribosome biogenesis
Ci	0000028	biological_process	ribosomal small subunit assembly
Ci	0003735	molecular_function	structural constituent of ribosome
Ci	0005840	cellular_component	ribosome
Ci	0006412	biological_process	translation
Ci	0022627	cellular_component	cytosolic small ribosomal subunit
Ci	1990904	cellular_component	ribonucleoprotein complex
CI	0005525	molecular_function	GTP binding
CI	0005634	cellular_component	nucleus
CI	0005730	cellular_component	nucleolus
CI	0042254	biological_process	ribosome biogenesis
Cj	0003735	molecular_function	structural constituent of ribosome
Cj	0005840	cellular_component	ribosome
Cj	0006412	biological_process	translation
Cj	1990904	cellular_component	ribonucleoprotein complex
CJ	0003723	molecular_function	RNA binding
CJ	0005730	cellular_component	nucleolus
CJ	0019843	molecular_function	rRNA binding
CJ	0042254	biological_process	ribosome biogenesis
CJ	1990904	cellular_component	ribonucleoprotein complex
Ck	0003735	molecular_function	structural constituent of ribosome
Ck	0005840	cellular_component	ribosome
Ck	0006412	biological_process	translation
Ck	0022627	cellular_component	cytosolic small ribosomal subunit
Ck	1990904	cellular_component	ribonucleoprotein complex
CK	0006364	biological_process	rRNA processing
CK	0019843	molecular_function	rRNA binding
CK	0042134	molecular_function	rRNA primary transcript binding
CK	0042254	biological_process	ribosome biogenesis
CK	1990904	cellular_component	ribonucleoprotein complex
Cl	0003676	molecular_function	nucleic acid binding
Cl	0003723	molecular_function	RNA binding
Cl	0003735	molecular_function	structural constituent of ribosome
Cl	0005829	cellular_component	cytosol
Cl	0005840	cellular_component	ribosome
Cl	0006412	biological_process	translation
Cl	0015935	cellular_component	small ribosomal subunit
Cl	1990904	cellular_component	ribonucleoprotein complex
CL	0005634	cellular_component	nucleus
CL	0005730	cellular_component	nucleolus
CL	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
CL	0006364	biological_process	rRNA processing
CL	0034457	cellular_component	Mpp10 complex
CL	0042254	biological_process	ribosome biogenesis
CL	1990904	cellular_component	ribonucleoprotein complex
Cm	0003735	molecular_function	structural constituent of ribosome
Cm	0005840	cellular_component	ribosome
Cm	0006412	biological_process	translation
Cm	1990904	cellular_component	ribonucleoprotein complex
CM	0005634	cellular_component	nucleus
CM	0005730	cellular_component	nucleolus
CM	0016567	biological_process	protein ubiquitination
CM	1990904	cellular_component	ribonucleoprotein complex
Cn	0003735	molecular_function	structural constituent of ribosome
Cn	0005840	cellular_component	ribosome
Cn	0006412	biological_process	translation
Cn	0015935	cellular_component	small ribosomal subunit
Cn	0022627	cellular_component	cytosolic small ribosomal subunit
Cn	1990904	cellular_component	ribonucleoprotein complex
CN	0006364	biological_process	rRNA processing
CN	0008168	molecular_function	methyltransferase activity
CN	0019843	molecular_function	rRNA binding
CN	0032259	biological_process	methylation
CN	0042254	biological_process	ribosome biogenesis
CN	0070037	molecular_function	rRNA (pseudouridine) methyltransferase activity
CN	0070475	biological_process	rRNA base methylation
Co	0003735	molecular_function	structural constituent of ribosome
Co	0005737	cellular_component	cytoplasm
Co	0005840	cellular_component	ribosome
Co	0006412	biological_process	translation
Co	0008168	molecular_function	methyltransferase activity
Co	0032259	biological_process	methylation
Co	1990904	cellular_component	ribonucleoprotein complex
CO	0006364	biological_process	rRNA processing
CO	0008168	molecular_function	methyltransferase activity
CO	0019843	molecular_function	rRNA binding
CO	0032259	biological_process	methylation
CO	0042254	biological_process	ribosome biogenesis
CO	0070037	molecular_function	rRNA (pseudouridine) methyltransferase activity
CO	0070475	biological_process	rRNA base methylation
Cp	0000028	biological_process	ribosomal small subunit assembly
Cp	0003735	molecular_function	structural constituent of ribosome
Cp	0005840	cellular_component	ribosome
Cp	0006412	biological_process	translation
Cp	0022627	cellular_component	cytosolic small ribosomal subunit
Cp	0030490	biological_process	maturation of SSU-rRNA
CP	0003676	molecular_function	nucleic acid binding
CP	0003723	molecular_function	RNA binding
CP	0005634	cellular_component	nucleus
CP	0005730	cellular_component	nucleolus
CP	0006364	biological_process	rRNA processing
CP	0042254	biological_process	ribosome biogenesis
CP	1990904	cellular_component	ribonucleoprotein complex
CQ	0003676	molecular_function	nucleic acid binding
CQ	0003723	molecular_function	RNA binding
CQ	0005634	cellular_component	nucleus
CQ	0005730	cellular_component	nucleolus
CQ	0005737	cellular_component	cytoplasm
CQ	0042254	biological_process	ribosome biogenesis
CR	0000154	biological_process	rRNA modification
CR	0005524	molecular_function	ATP binding
CR	0005634	cellular_component	nucleus
CR	0005730	cellular_component	nucleolus
CR	0006364	biological_process	rRNA processing
CR	0008033	biological_process	tRNA processing
CR	0008080	molecular_function	N-acetyltransferase activity
CR	0016072	biological_process	rRNA metabolic process
CR	0016746	molecular_function	acyltransferase activity
CR	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
CR	0042274	biological_process	ribosomal small subunit biogenesis
CR	0051391	biological_process	tRNA acetylation
CR	0051392	molecular_function	tRNA N-acetyltransferase activity
CR	1904812	biological_process	rRNA acetylation involved in maturation of SSU-rRNA
CS	0000154	biological_process	rRNA modification
CS	0005524	molecular_function	ATP binding
CS	0005634	cellular_component	nucleus
CS	0005730	cellular_component	nucleolus
CS	0006364	biological_process	rRNA processing
CS	0008033	biological_process	tRNA processing
CS	0008080	molecular_function	N-acetyltransferase activity
CS	0016072	biological_process	rRNA metabolic process
CS	0016746	molecular_function	acyltransferase activity
CS	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
CS	0042274	biological_process	ribosomal small subunit biogenesis
CS	0051391	biological_process	tRNA acetylation
CS	0051392	molecular_function	tRNA N-acetyltransferase activity
CS	1904812	biological_process	rRNA acetylation involved in maturation of SSU-rRNA
CT	0005634	cellular_component	nucleus
CT	0005730	cellular_component	nucleolus
CW	0005634	cellular_component	nucleus
CW	0005730	cellular_component	nucleolus
CW	0006364	biological_process	rRNA processing
CW	0042254	biological_process	ribosome biogenesis
CX	0043229	cellular_component	intracellular organelle
CY	1990904	cellular_component	ribonucleoprotein complex
CZ	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CZ	0005634	cellular_component	nucleus
CZ	0005730	cellular_component	nucleolus
UA	0005730	cellular_component	nucleolus
UA	0042254	biological_process	ribosome biogenesis
UB	0005634	cellular_component	nucleus
UB	0005730	cellular_component	nucleolus
UB	0032040	cellular_component	small-subunit processome
UB	0042254	biological_process	ribosome biogenesis
UE	0005634	cellular_component	nucleus
UF	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UF	0005730	cellular_component	nucleolus
UF	0006396	biological_process	RNA processing
UF	0030515	molecular_function	snoRNA binding
UG	0005634	cellular_component	nucleus
UG	0005730	cellular_component	nucleolus
UH	0005634	cellular_component	nucleus
UI	0005634	cellular_component	nucleus
UJ	0005634	cellular_component	nucleus
UJ	0005730	cellular_component	nucleolus
UJ	0006364	biological_process	rRNA processing
UJ	0042254	biological_process	ribosome biogenesis
UJ	1990904	cellular_component	ribonucleoprotein complex
UK	0005634	cellular_component	nucleus
UK	0005730	cellular_component	nucleolus
UK	0006364	biological_process	rRNA processing
UK	0032040	cellular_component	small-subunit processome
UK	0042254	biological_process	ribosome biogenesis
UK	1990904	cellular_component	ribonucleoprotein complex
UL	0005730	cellular_component	nucleolus
UL	0042254	biological_process	ribosome biogenesis
UM	0006364	biological_process	rRNA processing
UM	0032040	cellular_component	small-subunit processome
UN	0005634	cellular_component	nucleus
UN	0005730	cellular_component	nucleolus
UN	0006364	biological_process	rRNA processing
UN	0032040	cellular_component	small-subunit processome
UO	0005634	cellular_component	nucleus
UO	0005730	cellular_component	nucleolus
UO	0006364	biological_process	rRNA processing
UP	0006364	biological_process	rRNA processing
UP	0030515	molecular_function	snoRNA binding
UQ	0003723	molecular_function	RNA binding
UQ	0005634	cellular_component	nucleus
UQ	0005730	cellular_component	nucleolus
UQ	0006364	biological_process	rRNA processing
UQ	0032040	cellular_component	small-subunit processome
UQ	0042254	biological_process	ribosome biogenesis
UQ	0045943	biological_process	positive regulation of transcription by RNA polymerase I
UR	0005730	cellular_component	nucleolus
UR	0006364	biological_process	rRNA processing
US	0042254	biological_process	ribosome biogenesis
US	0043231	cellular_component	intracellular membrane-bounded organelle
UU	0006364	biological_process	rRNA processing
UU	0032040	cellular_component	small-subunit processome
UV	0003723	molecular_function	RNA binding
UV	0005634	cellular_component	nucleus
UV	0005730	cellular_component	nucleolus
UV	0006364	biological_process	rRNA processing
UV	0042254	biological_process	ribosome biogenesis
UV	1990904	cellular_component	ribonucleoprotein complex
UX	0032040	cellular_component	small-subunit processome
UZ	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN UX 200

Chain	Residue
UX	CYS94
UX	CYS123
UX	HIS125
UX	CYS133

site_id	AC2
Number of Residues	8
Details	binding site for residue GTP CI 1201

Chain	Residue
CI	HIS172
CI	LEU175
CI	VAL209
CI	VAL79
CI	GLY80
CI	LYS81
CI	THR82
CI	THR83

site_id	AC3
Number of Residues	2
Details	binding site for residue MG CI 1202

Chain	Residue
CI	THR82
CI	GLU118

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DEDEDKQVQigDM

Chain	Residue	Details
UE	ASP328-MET340

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsLMmhgrnnGKKlmavrIVahA

Chain	Residue	Details
Cc	GLU78-ALA104

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GyvILTTSaGIMdheeAR

Chain	Residue	Details
Cm	GLY100-ARG117

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPtPSD

Chain	Residue	Details
Ci	LEU115-ASP137

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
Cn	LYS62-ARG69

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDmVvVgQcRPLS

Chain	Residue	Details
Ck	GLY125-SER137

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VETsVIGSVATDRSIiL

Chain	Residue	Details
CM	VAL208-LEU224

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhtSQvyAvrqAiAKSI

Chain	Residue	Details
Cj	GLY71-ILE89

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdSkfrLilIesrihrLarY

Chain	Residue	Details
Ch	VAL98-TYR128

site_id	PS00528
Number of Residues	15
Details	RIBOSOMAL_S4E Ribosomal protein S4e signature. HqKRLSaPshWlLdK

Chain	Residue	Details
Cb	HIS8-LYS22

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. YGggKTtGFAlIYDSpealkkfE

Chain	Residue	Details
Co	TYR395-GLU417

site_id	PS00566
Number of Residues	15
Details	FIBRILLARIN Fibrillarin signature. GAVYAVEFShRsgRD

Chain	Residue	Details
CA	GLY178-ASP192

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. ITGGnDkqGfPM

Chain	Residue	Details
Cd	ILE52-MET63

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtlVYKlglAkSihhARvLI

Chain	Residue	Details
Cg	LEU103-ILE127

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHywGlrVRGQ

Chain	Residue	Details
Cl	ARG123-GLN136

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGaaDgAIKIWDI

Chain	Residue	Details
UM	LEU126-ILE140
UG	MET315-ILE329
UU	VAL637-PHE651
UU	ILE722-LEU736
UA	ILE355-VAL369
UA	LEU397-LEU411
UM	VAL615-LEU629
UO	LEU160-LEU174
UO	LEU205-ALA219
UL	LEU125-LEU139
UL	LEU189-LEU203
UL	MET440-ILE454
UL	VAL523-PHE537
CM	ILE82-LEU96

site_id	PS00948
Number of Residues	14
Details	RIBOSOMAL_S7E Ribosomal protein S7e signature. RLtRELEKKFSdRH

Chain	Residue	Details
Ce	ARG82-HIS95

site_id	PS00961
Number of Residues	9
Details	RIBOSOMAL_S28E Ribosomal protein S28e signature. ESEREARrL

Chain	Residue	Details
Cp	GLU59-LEU67

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CeeknVPYvyVpSKvaLG

Chain	Residue	Details
CE	CYS72-GLY89

site_id	PS01191
Number of Residues	13
Details	RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRIfEvCLaDL

Chain	Residue	Details
Ca	LEU61-LEU73

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)