6RFU

In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of ATP and GMP as genuine co-factors

Summary for 6RFU

• Entry DOI: 10.2210/pdb6rfu/pdb
• Descriptor: Inosine-5'-monophosphate dehydrogenase, ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: imp dehydrogenase, trypanosoma brucei, in cellulo crystallization, fel, immunosuppressant
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 113300.16

Authors

Nass, K.,Redecke, L.,Perbandt, M.,Yefanov, O.,Gabdulkhakov, A.,Duszenko, M.,Chapman, H.N.,Betzel, C. (deposition date: 2019-04-16, release date: 2020-02-19, Last modification date: 2024-01-24)

• Primary citation: Nass, K.,Redecke, L.,Perbandt, M.,Yefanov, O.,Klinge, M.,Koopmann, R.,Stellato, F.,Gabdulkhakov, A.,Schonherr, R.,Rehders, D.,Lahey-Rudolph, J.M.,Aquila, A.,Barty, A.,Basu, S.,Doak, R.B.,Duden, R.,Frank, M.,Fromme, R.,Kassemeyer, S.,Katona, G.,Kirian, R.,Liu, H.,Majoul, I.,Martin-Garcia, J.M.,Messerschmidt, M.,Shoeman, R.L.,Weierstall, U.,Westenhoff, S.,White, T.A.,Williams, G.J.,Yoon, C.H.,Zatsepin, N.,Fromme, P.,Duszenko, M.,Chapman, H.N.,Betzel, C.; In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors.; Nat Commun, 11:620-620, 2020; PubMed: 32001697; DOI: 10.1038/s41467-020-14484-w

Experimental method

X-RAY DIFFRACTION (2.8 Å)