6R9S
Human Cyclophilin D in complex with bicyclic fragment
Summary for 6R9S
Entry DOI | 10.2210/pdb6r9s/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase F, mitochondrial, (1~{R},9~{R},10~{S})-4-fluoranyl-12-oxa-8-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5-trien-10-ol, PENTAETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | cyclophilin, beta barrel, prolyl cis/trans isomerase, mitoc, isomerase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18599.13 |
Authors | Graedler, U. (deposition date: 2019-04-04, release date: 2019-11-27, Last modification date: 2024-01-24) |
Primary citation | Gradler, U.,Schwarz, D.,Blaesse, M.,Leuthner, B.,Johnson, T.L.,Bernard, F.,Jiang, X.,Marx, A.,Gilardone, M.,Lemoine, H.,Roche, D.,Jorand-Lebrun, C. Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies. Bioorg.Med.Chem.Lett., 29:126717-126717, 2019 Cited by PubMed: 31635932DOI: 10.1016/j.bmcl.2019.126717 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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