6R4V
Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate
Summary for 6R4V
Entry DOI | 10.2210/pdb6r4v/pdb |
Descriptor | Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, IBANDRONATE, ... (5 entities in total) |
Functional Keywords | bisphosphonate, ibandronate, geranylgeranyl diphosphate, prenyltransferase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 215130.43 |
Authors | Lisnyansky, M.,Giladi, M.,Haitin, Y. (deposition date: 2019-03-24, release date: 2019-09-18, Last modification date: 2024-01-24) |
Primary citation | Lisnyansky, M.,Yariv, E.,Segal, O.,Marom, M.,Loewenstein, A.,Ben-Tal, N.,Giladi, M.,Haitin, Y. Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis. Mol.Pharmacol., 96:580-588, 2019 Cited by PubMed: 31427399DOI: 10.1124/mol.119.117499 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.202 Å) |
Structure validation
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