6R0Q
Mutant cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with thalidomide metabolite alpha-(o-carboxybenzamido)glutarimide
Summary for 6R0Q
Entry DOI | 10.2210/pdb6r0q/pdb |
Descriptor | Cereblon isoform 4, ALA-ALA-ALA, ALA-ALA-ALA-ALA, ... (6 entities in total) |
Functional Keywords | signaling protein, proteolysis targeting chimera, protac, protein degradation, hydrolysis product |
Biological source | Magnetospirillum gryphiswaldense MSR-1 More |
Total number of polymer chains | 8 |
Total formula weight | 57611.00 |
Authors | Heim, C.,Hartmann, M.D. (deposition date: 2019-03-13, release date: 2019-08-07, Last modification date: 2024-01-24) |
Primary citation | Heim, C.,Pliatsika, D.,Mousavizadeh, F.,Bar, K.,Hernandez Alvarez, B.,Giannis, A.,Hartmann, M.D. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J.Med.Chem., 62:6615-6629, 2019 Cited by PubMed: 31251063DOI: 10.1021/acs.jmedchem.9b00454 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report