6R0Q

Mutant cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with thalidomide metabolite alpha-(o-carboxybenzamido)glutarimide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Cereblon isoform 4	polymer	124	13766.5	4	UniProt (A4TVL0)	Magnetospirillum gryphiswaldense MSR-1
2	E, F, G (F, E, G)	ALA-ALA-ALA	polymer	3	273.3	3		Magnetospirillum gryphiswaldense MSR-1
3	H (H)	ALA-ALA-ALA-ALA	polymer	4	358.4	1		Magnetospirillum gryphiswaldense MSR-1
4	I, K, M, O (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	J, L, N, P (A, B, C, D)	2-[[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]carbamoyl]benzoic acid	non-polymer		276.2	4	Chemie (JNW)
6	Q, R, S, T, U... (A, B, C, D, E...)	water	water		18.0	421	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 124 (UniProt: A4TVL0)

PDB	External Database	Details
His 52	Ala 52	engineered mutation
Tyr 54	Met 54	engineered mutation
His 56	Phe 56	engineered mutation
Asn 68	Arg 68	engineered mutation
Arg 72	Ala 72	engineered mutation
Val 87	Ile 87	engineered mutation
Gln 89	Leu 89	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	56244.4
Non-Polymers*	Number of molecules	8
	Total formula weight	1366.6
All*	Total formula weight	57611.0

*Water molecules are not included.