6R0Q
Mutant cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with thalidomide metabolite alpha-(o-carboxybenzamido)glutarimide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Cereblon isoform 4 | polymer | 124 | 13766.5 | 4 | UniProt (A4TVL0) In PDB | Magnetospirillum gryphiswaldense MSR-1 | |
2 | F, E, G | ALA-ALA-ALA | polymer | 3 | 273.3 | 3 | Magnetospirillum gryphiswaldense MSR-1 | ||
3 | H | ALA-ALA-ALA-ALA | polymer | 4 | 358.4 | 1 | Magnetospirillum gryphiswaldense MSR-1 | ||
4 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
5 | A, B, C, D | 2-[[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]carbamoyl]benzoic acid | non-polymer | 276.2 | 4 | Chemie (JNW) | |||
6 | water | water | 18.0 | 421 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 124 (UniProt: A4TVL0)
PDB | External Database | Details |
---|---|---|
His 52 | Ala 52 | engineered mutation |
Tyr 54 | Met 54 | engineered mutation |
His 56 | Phe 56 | engineered mutation |
Asn 68 | Arg 68 | engineered mutation |
Arg 72 | Ala 72 | engineered mutation |
Val 87 | Ile 87 | engineered mutation |
Gln 89 | Leu 89 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 56244.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1366.6 | |
All* | Total formula weight | 57611.0 |