6QMR
Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid
Summary for 6QMR
Entry DOI | 10.2210/pdb6qmr/pdb |
Descriptor | Complement factor D, 2-[2-[[3-[3-[(1~{S})-1-azanyl-2-oxidanyl-ethyl]phenyl]phenyl]methoxy]phenyl]ethanoic acid (3 entities in total) |
Functional Keywords | complement factor d, inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 164852.21 |
Authors | Karki, R.,Powers, J.,Mainolfi, N.,Anderson, K.,Belanger, D.,Liu, D.,Jendza, K.,Gelin, C.F.,Solovay, C.,Mac Sweeeny, A.,Delgado, O.,Crowley, M.,Liao, S.-M.,Argikar, U.A.,Flohr, S.,La Bonte, L.R.,Lorthiois, E.L.,Vulpetti, A.,Cumin, F.,Brown, A.,Adams, C.,Jaffee, B.,Mogi, M. (deposition date: 2019-02-08, release date: 2019-04-24, Last modification date: 2024-01-24) |
Primary citation | Karki, R.G.,Powers, J.,Mainolfi, N.,Anderson, K.,Belanger, D.B.,Liu, D.,Ji, N.,Jendza, K.,Gelin, C.F.,Mac Sweeney, A.,Solovay, C.,Delgado, O.,Crowley, M.,Liao, S.M.,Argikar, U.A.,Flohr, S.,La Bonte, L.R.,Lorthiois, E.L.,Vulpetti, A.,Brown, A.,Long, D.,Prentiss, M.,Gradoux, N.,de Erkenez, A.,Cumin, F.,Adams, C.,Jaffee, B.,Mogi, M. Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. J.Med.Chem., 62:4656-4668, 2019 Cited by PubMed: 30995036DOI: 10.1021/acs.jmedchem.9b00271 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report