6QLW

Cathepsin-K in complex with MIV-710

Summary for 6QLW

• Entry DOI: 10.2210/pdb6qlw/pdb
• Related: 6QL8
• Descriptor: Cathepsin K, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{S})-6-chloranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-[5-fluoranyl-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: inhibitor complex, lysosomal cysteine proteinase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 97337.30

Authors

Derbyshire, D.J. (deposition date: 2019-02-01, release date: 2020-02-19)

• Primary citation: Derbyshire, D.J.; Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)