6QLW

Cathepsin-K in complex with MIV-710

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue J5T A 301

Chain	Residue
A	GLN19
A	GLY65
A	GLY66
A	ASN161
A	HOH466
A	HOH489
A	HOH494
B	TYR67
B	J5T301
A	GLY23
A	SER24
A	CYS25
A	TRP26
A	GLU59
A	ASN60
A	ASP61
A	GLY64

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 302

Chain	Residue
A	SER95

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 303

Chain	Residue
A	LYS122
A	LYS176
A	ARG198
A	ASN199

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 304

Chain	Residue
A	LYS122
A	ARG123

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 305

Chain	Residue
A	GLU59
A	ASN70
A	GLN73
A	HOH484
A	HOH565
B	ASN70

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL B 302

Chain	Residue
B	LYS122
B	LYS176
B	ARG198
B	ASN199

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL C 302

Chain	Residue
C	ARG111
C	HOH634

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL C 303

Chain	Residue
C	LYS122
C	ARG123

---

site_id	AC9
Number of Residues	5
Details	binding site for residue NA C 304

Chain	Residue
C	GLU59
C	ASN70
C	GLN73
C	HOH482
C	HOH568

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL D 302

Chain	Residue
D	LYS122
D	LYS176
D	ARG198
D	ASN199

---

site_id	AD2
Number of Residues	19
Details	binding site for Di-peptide J5T B 301 and CYS B 25

Chain	Residue
A	TYR67
A	J5T301
B	GLN19
B	GLY23
B	SER24
B	TRP26
B	ALA27
B	PHE28
B	SER29
B	GLU59
B	ASN60
B	ASP61
B	GLY64
B	GLY65
B	GLY66
B	ASN161
B	HIS162
B	ALA163
B	HOH546

---

site_id	AD3
Number of Residues	21
Details	binding site for Di-peptide J5T C 301 and CYS C 25

Chain	Residue
C	GLN19
C	GLY23
C	SER24
C	TRP26
C	ALA27
C	PHE28
C	SER29
C	GLU59
C	ASN60
C	ASP61
C	GLY64
C	GLY65
C	GLY66
C	TYR67
C	LEU160
C	ASN161
C	HIS162
C	ALA163
C	HOH423
C	HOH458
C	HOH510

---

site_id	AD4
Number of Residues	18
Details	binding site for Di-peptide J5T D 301 and CYS D 25

Chain	Residue
D	GLY66
D	ASN161
D	HIS162
D	ALA163
D	HOH458
D	HOH481
D	GLN19
D	GLY23
D	SER24
D	TRP26
D	ALA27
D	PHE28
D	SER29
D	GLU59
D	ASN60
D	ASP61
D	GLY64
D	GLY65

---

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS

Chain	Residue	Details
A	GLN19-SER30

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG

Chain	Residue	Details
A	LEU160-GLY170

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM

Chain	Residue	Details
A	HIS177-MET196

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	CYS25
D	CYS25
D	HIS162
D	ASN182
A	HIS162
A	ASN182
B	CYS25
B	HIS162
B	ASN182
C	CYS25
C	HIS162
C	ASN182

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