6QBA
Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold
Summary for 6QBA
Entry DOI | 10.2210/pdb6qba/pdb |
Descriptor | Retinol-binding protein 4, DNA-binding protein 7a, 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid, ... (8 entities in total) |
Functional Keywords | lipocalin, rbp4, retinol binding protein, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 29281.70 |
Authors | Mlynek, G.,Brey, C.U.,Djinovic-Carugo, K.,Puehringer, D. (deposition date: 2018-12-20, release date: 2020-06-03, Last modification date: 2024-01-24) |
Primary citation | Zajc, C.U.,Dobersberger, M.,Schaffner, I.,Mlynek, G.,Puhringer, D.,Salzer, B.,Djinovic-Carugo, K.,Steinberger, P.,De Sousa Linhares, A.,Yang, N.J.,Obinger, C.,Holter, W.,Traxlmayr, M.W.,Lehner, M. A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Proc.Natl.Acad.Sci.USA, 117:14926-14935, 2020 Cited by PubMed: 32554495DOI: 10.1073/pnas.1911154117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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