6Q9L

HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 9 AT 1.13A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Summary for 6Q9L

• Entry DOI: 10.2210/pdb6q9l/pdb
• Related: 4DIJ
• Descriptor: E3 ubiquitin-protein ligase Mdm2, [6-chloranyl-3-[3-[[4-chloranyl-2-(hydroxymethyl)phenyl]methyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]-[(3~{S})-3-[3-(dimethylamino)propyl-methyl-amino]pyrrolidin-1-yl]methanone, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: ppi with p53, inhibitor complex, cell cycle, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 23915.02

Authors

Kallen, J. (deposition date: 2018-12-18, release date: 2019-05-15, Last modification date: 2024-01-24)

• Primary citation: Kallen, J.,Izaac, A.,Chau, S.,Wirth, E.,Schoepfer, J.,Mah, R.,Schlapbach, A.,Stutz, S.,Vaupel, A.,Guagnano, V.,Masuya, K.,Stachyra, T.M.,Salem, B.,Chene, P.,Gessier, F.,Holzer, P.,Furet, P.; Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.; Chemmedchem, 14:1305-1314, 2019; PubMed: 31066983; DOI: 10.1002/cmdc.201900201

Experimental method

X-RAY DIFFRACTION (1.13 Å)