6Q9L

HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 9 AT 1.13A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue HTZ A 201

Chain	Residue
A	LEU54
A	HOH325
A	HOH331
A	HOH333
A	HOH371
B	PHE55
A	GLY58
A	ILE61
A	MET62
A	TYR67
A	GLN72
A	VAL93
A	HIS96
A	HOH306

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site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 202

Chain	Residue
A	TYR100

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site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 203

Chain	Residue
A	HIS96
A	HOH420

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site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 204

Chain	Residue
A	THR49

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site_id	AC5
Number of Residues	14
Details	binding site for residue HTZ B 201

Chain	Residue
A	GLU52
A	PHE55
B	LEU54
B	GLY58
B	ILE61
B	MET62
B	GLN72
B	VAL93
B	HIS96
B	HOH312
B	HOH318
B	HOH334
B	HOH341
B	HOH358

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site_id	AC6
Number of Residues	1
Details	binding site for residue CL B 202

Chain	Residue
B	TYR100

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site_id	AC7
Number of Residues	2
Details	binding site for residue CL B 203

Chain	Residue
A	HOH436
B	HIS96

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site_id	AC8
Number of Residues	3
Details	binding site for residue CL B 204

Chain	Residue
A	HOH390
B	ARG29
B	HOH317

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site_id	AC9
Number of Residues	1
Details	binding site for residue CL B 205

Chain	Residue
B	SER92

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site_id	AD1
Number of Residues	1
Details	binding site for residue CL B 206

Chain	Residue
B	THR49

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