6Q9L
HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 9 AT 1.13A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11156.1 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
2 | A, B | [6-chloranyl-3-[3-[[4-chloranyl-2-(hydroxymethyl)phenyl]methyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]-[(3~{S})-3-[3-(dimethylamino)propyl-methyl-amino]pyrrolidin-1-yl]methanone | non-polymer | 659.6 | 2 | Chemie (HTZ) | |||
3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
4 | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 111 (UniProt: Q00987)
PDB | External Database | Details |
---|---|---|
Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 22312.1 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1602.9 | |
All* | Total formula weight | 23915.0 |